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Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry

Author

Listed:
  • Matthew J. Evans

    (Center for the Study of Hepatitis C, The Rockefeller University, 1230 York Ave, New York 10021, USA)

  • Thomas von Hahn

    (Center for the Study of Hepatitis C, The Rockefeller University, 1230 York Ave, New York 10021, USA)

  • Donna M. Tscherne

    (Center for the Study of Hepatitis C, The Rockefeller University, 1230 York Ave, New York 10021, USA)

  • Andrew J. Syder

    (Center for the Study of Hepatitis C, The Rockefeller University, 1230 York Ave, New York 10021, USA)

  • Maryline Panis

    (Center for the Study of Hepatitis C, The Rockefeller University, 1230 York Ave, New York 10021, USA)

  • Benno Wölk

    (Center for the Study of Hepatitis C, The Rockefeller University, 1230 York Ave, New York 10021, USA)

  • Theodora Hatziioannou

    (Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Avenue, New York 10016, USA)

  • Jane A. McKeating

    (Center for the Study of Hepatitis C, The Rockefeller University, 1230 York Ave, New York 10021, USA
    Present address: Division of Immunity and Infection, Institute of Biomedical Research, Medical School, University of Birmingham, Birmingham B15 2TT, UK.)

  • Paul D. Bieniasz

    (Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Avenue, New York 10016, USA)

  • Charles M. Rice

    (Center for the Study of Hepatitis C, The Rockefeller University, 1230 York Ave, New York 10021, USA)

Abstract

Hepatitis C co-factor Claudin-1, a tight junction protein expressed in human liver, has been identified as an essential entry co-factor for hepatitis C virus. Like the CD81 co-receptor, claudin-1 spans the cell membrane four times with two extracellular loops. It functions in the hepatitis C virus entry process at a post-binding and pre-fusion step. This discovery provides insights into the mechanism of viral entry into liver cells, and a potential new target for antiviral drugs.

Suggested Citation

  • Matthew J. Evans & Thomas von Hahn & Donna M. Tscherne & Andrew J. Syder & Maryline Panis & Benno Wölk & Theodora Hatziioannou & Jane A. McKeating & Paul D. Bieniasz & Charles M. Rice, 2007. "Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry," Nature, Nature, vol. 446(7137), pages 801-805, April.
    • Handle: RePEc:nat:nature:v:446:y:2007:i:7137:d:10.1038_nature05654
    DOI: 10.1038/nature05654
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    Cited by:

    1. Mphatso Kalemera & Dilyana Mincheva & Joe Grove & Christopher J R Illingworth, 2019. "Building a mechanistic mathematical model of hepatitis C virus entry," PLOS Computational Biology, Public Library of Science, vol. 15(3), pages 1-26, March.
    2. Pranesh Padmanabhan & Narendra M Dixit, 2011. "Mathematical Model of Viral Kinetics In Vitro Estimates the Number of E2-CD81 Complexes Necessary for Hepatitis C Virus Entry," PLOS Computational Biology, Public Library of Science, vol. 7(12), pages 1-11, December.
    3. Pranesh Padmanabhan & Narendra M Dixit, 2012. "Viral Kinetics Suggests a Reconciliation of the Disparate Observations of the Modulation of Claudin-1 Expression on Cells Exposed to Hepatitis C Virus," PLOS ONE, Public Library of Science, vol. 7(4), pages 1-7, April.
    4. Ashish Kumar & Tiana C. Rohe & Elizabeth J. Elrod & Abdul G. Khan & Altaira D. Dearborn & Ryan Kissinger & Arash Grakoui & Joseph Marcotrigiano, 2023. "Regions of hepatitis C virus E2 required for membrane association," Nature Communications, Nature, vol. 14(1), pages 1-10, December.

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