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Chemical rescue of cleft palate and midline defects in conditional GSK-3β mice

Author

Listed:
  • Karen J. Liu

    (The Department of Pathology,
    The Stanford Institute for Stem Cell Biology and Regenerative Medicine,
    Present addresses: Department of Craniofacial Development, King’s College London, London SE1 9RT, UK (K.J.L.); Department of Immunology Diagnostics, Genentech, 1 DNA Way, South San Francisco, California 94080, USA (J.R.A.))

  • Joseph R. Arron

    (The Department of Pathology,
    Present addresses: Department of Craniofacial Development, King’s College London, London SE1 9RT, UK (K.J.L.); Department of Immunology Diagnostics, Genentech, 1 DNA Way, South San Francisco, California 94080, USA (J.R.A.))

  • Kryn Stankunas

    (Department of Developmental Biology,)

  • Gerald R. Crabtree

    (The Department of Pathology,
    Department of Developmental Biology,
    Howard Hughes Medical Institute, and the)

  • Michael T. Longaker

    (The Stanford Institute for Stem Cell Biology and Regenerative Medicine,
    Stanford University School of Medicine, Palo Alto, California 94305, USA.)

Abstract

Cleft palate repair The development of a novel chemical genetics strategy to regulate an important developmental protein (GSK-3β) in a mouse fetus in a reversible time-controlled fashion could have important implications. Remarkably, this control can be achieved within the mother's uterus. GSK-3β (glycogen synthase kinase-β) is involved in many different biological processes, and mice engineered to lack it have cleft palates: this birth defect is reversed by the in utero rescue. Several key advances are required before this research can have clinical relevance, but the demonstration that small-molecule based therapy can prevent a birth defect is an important proof of principle.

Suggested Citation

  • Karen J. Liu & Joseph R. Arron & Kryn Stankunas & Gerald R. Crabtree & Michael T. Longaker, 2007. "Chemical rescue of cleft palate and midline defects in conditional GSK-3β mice," Nature, Nature, vol. 446(7131), pages 79-82, March.
    • Handle: RePEc:nat:nature:v:446:y:2007:i:7131:d:10.1038_nature05557
    DOI: 10.1038/nature05557
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    Cited by:

    1. Jeremie Oliver Piña & Resmi Raju & Daniela M. Roth & Emma Wentworth Winchester & Parna Chattaraj & Fahad Kidwai & Fabio R. Faucz & James Iben & Apratim Mitra & Kiersten Campbell & Gus Fridell & Caroli, 2023. "Multimodal spatiotemporal transcriptomic resolution of embryonic palate osteogenesis," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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