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Scratching the surface of skin development

Author

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  • Elaine Fuchs

    (Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University)

Abstract

The epidermis and its appendages develop from a single layer of multipotent embryonic progenitor keratinocytes. Embryonic stem cells receive cues from their environment that instruct them to commit to a particular differentiation programme and generate a stratified epidermis, hair follicles or sebaceous glands. Exciting recent developments have focused on how adult skin epithelia maintain populations of stem cells for use in the natural cycles of hair follicle regeneration and for re-epithelialization in response to wounding.

Suggested Citation

  • Elaine Fuchs, 2007. "Scratching the surface of skin development," Nature, Nature, vol. 445(7130), pages 834-842, February.
    • Handle: RePEc:nat:nature:v:445:y:2007:i:7130:d:10.1038_nature05659
    DOI: 10.1038/nature05659
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    Cited by:

    1. Alexander L. Rusanov & Daniil D. Romashin & Peter M. Kozhin & Maxim N. Karagyaur & Dmitry S. Loginov & Olga V. Tikhonova & Victor G. Zgoda & Nataliya G. Luzgina, 2022. "Impact of p53 Knockout on Protein Data Set of HaCaT Cells in Confluent and Subconfluent Conditions," Data, MDPI, vol. 7(3), pages 1-8, February.
    2. Elle Koren & Alona Feldman & Marianna Yusupova & Avihay Kadosh & Egor Sedov & Roi Ankawa & Yahav Yosefzon & Waseem Nasser & Stefanie Gerstberger & Liam B. Kimel & Noa Priselac & Samara Brown & Sam Sha, 2022. "Thy1 marks a distinct population of slow-cycling stem cells in the mouse epidermis," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    3. Jun Li & Jie Ma & Qiyu Zhang & Huizi Gong & Dunqin Gao & Yujie Wang & Biyou Li & Xiao Li & Heyi Zheng & Zhihong Wu & Yunping Zhu & Ling Leng, 2022. "Spatially resolved proteomic map shows that extracellular matrix regulates epidermal growth," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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