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Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase

Author

Listed:
  • Ya-Chieh Hsu

    (Program in Developmental Biology,)

  • Joshua J. Chern

    (and)

  • Yi Cai

    (Institute of Biosciences and Technology, Texas A&M University System Health Science Center, Houston, Texas 77030, USA)

  • Mingyao Liu

    (Institute of Biosciences and Technology, Texas A&M University System Health Science Center, Houston, Texas 77030, USA)

  • Kwang-Wook Choi

    (Program in Developmental Biology,
    and
    Baylor College of Medicine, and)

Abstract

Mixed messages Translationally controlled tumour protein (TCTP) has been implicated in tumorigenesis in mammalian cells, but its in vivo role is still unknown. Now a study in Drosophila reveals an important connection between TCTP and the TSC signalling pathway. Tuberous sclerosis or tuberous sclerosis complex (TSC) is a benign tumour syndrome caused by mutations in either TSC1 or TSC2 tumour suppressor genes, and TSC signalling is a conserved pathway for growth control. The genetic and biochemical evidence in Drosophila suggests that TCTP is a direct regulator of Rheb, a Ras superfamily GTPase that is part of the TSC pathway. TCTP is therefore a potential therapeutic target for tuberous sclerosis.

Suggested Citation

  • Ya-Chieh Hsu & Joshua J. Chern & Yi Cai & Mingyao Liu & Kwang-Wook Choi, 2007. "Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase," Nature, Nature, vol. 445(7129), pages 785-788, February.
    • Handle: RePEc:nat:nature:v:445:y:2007:i:7129:d:10.1038_nature05528
    DOI: 10.1038/nature05528
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    Cited by:

    1. Hongliang Zhang & Julia Quintana & Koray Ütkür & Lorenz Adrian & Harmen Hawer & Klaus Mayer & Xiaodi Gong & Leonardo Castanedo & Anna Schulten & Nadežda Janina & Marcus Peters & Markus Wirtz & Ulrich , 2022. "Translational fidelity and growth of Arabidopsis require stress-sensitive diphthamide biosynthesis," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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