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CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast

Author

Listed:
  • Seiji Tanaka

    (National Institute of Genetics, Research Organization of Information and Systems
    SOKENDAI
    CREST, Kawaguchi)

  • Toshiko Umemori

    (National Institute of Genetics, Research Organization of Information and Systems
    CREST, Kawaguchi)

  • Kazuyuki Hirai

    (National Institute of Genetics, Research Organization of Information and Systems
    CREST, Kawaguchi)

  • Sachiko Muramatsu

    (National Institute of Genetics, Research Organization of Information and Systems)

  • Yoichiro Kamimura

    (National Institute of Genetics, Research Organization of Information and Systems
    SOKENDAI
    CREST, Kawaguchi
    Johns Hopkins University School of Medicine)

  • Hiroyuki Araki

    (National Institute of Genetics, Research Organization of Information and Systems
    SOKENDAI
    CREST, Kawaguchi)

Abstract

This paper, one of two published that show Sld2 and Sld3 constitute the minimal group of cyclin-dependent kinase (CDK) targets necessary to promote replication, also finds that the function of G1 CDKs in replication is not just to activate the S-phase CDKs, but also to regulate the Cdc7 kinase regulatory subunit, Dbf4.

Suggested Citation

  • Seiji Tanaka & Toshiko Umemori & Kazuyuki Hirai & Sachiko Muramatsu & Yoichiro Kamimura & Hiroyuki Araki, 2007. "CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast," Nature, Nature, vol. 445(7125), pages 328-332, January.
    • Handle: RePEc:nat:nature:v:445:y:2007:i:7125:d:10.1038_nature05465
    DOI: 10.1038/nature05465
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    Cited by:

    1. Aftab Amin & Cheung Man Hei & Chun Liang & Aftab Amin & Cheung Man Hei & Chun Liang & Chun Liang & Aftab Amin & Cheung Man Hei & Chun Liang, 2019. "DNA Replication-Initiation Proteins in Eukaryotic Cells," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 22(5), pages 17042-17049, December.
    2. Lorenza Garribba & Giuseppina De Feudis & Valentino Martis & Martina Galli & Marie Dumont & Yonatan Eliezer & René Wardenaar & Marica Rosaria Ippolito & Divya Ramalingam Iyer & Andréa E. Tijhuis & Dia, 2023. "Short-term molecular consequences of chromosome mis-segregation for genome stability," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Juan Manuel Valverde & Geronimo Dubra & Michael Phillips & Austin Haider & Carlos Elena-Real & Aurélie Fournet & Emile Alghoul & Dhanvantri Chahar & Nuria Andrés-Sanchez & Matteo Paloni & Pau Bernadó , 2023. "A cyclin-dependent kinase-mediated phosphorylation switch of disordered protein condensation," Nature Communications, Nature, vol. 14(1), pages 1-23, December.
    4. Anna C. Papageorgiou & Michaela Pospisilova & Jakub Cibulka & Raghib Ashraf & Christopher A. Waudby & Pavel Kadeřávek & Volha Maroz & Karel Kubicek & Zbynek Prokop & Lumir Krejci & Konstantinos Tripsi, 2023. "Recognition and coacervation of G-quadruplexes by a multifunctional disordered region in RECQ4 helicase," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    5. Karl-Uwe Reusswig & Julia Bittmann & Martina Peritore & Mathilde Courtes & Benjamin Pardo & Michael Wierer & Matthias Mann & Boris Pfander, 2022. "Unscheduled DNA replication in G1 causes genome instability and damage signatures indicative of replication collisions," Nature Communications, Nature, vol. 13(1), pages 1-20, December.

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