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p63 protects the female germ line during meiotic arrest

Author

Listed:
  • Eun-Kyung Suh

    (Department of Cell Biology)

  • Annie Yang

    (Department of Cell Biology
    Department of Biological Chemistry and Molecular Pharmacology)

  • Arminja Kettenbach

    (Department of Cell Biology)

  • Casimir Bamberger

    (Department of Cell Biology)

  • Ala H. Michaelis

    (Department of Cell Biology)

  • Zhou Zhu

    (Department of Genetics)

  • Julia A. Elvin

    (Brigham and Women’s Hospital)

  • Roderick T. Bronson

    (Harvard Medical School)

  • Christopher P. Crum

    (Brigham and Women’s Hospital)

  • Frank McKeon

    (Department of Cell Biology)

Abstract

Whereas the tumour suppressor gene p53 plays a key role in monitoring and maintaining genomic integrity in somatic cells, it is now shown that in oocytes, a p53 family member, p63 (but not p53 itself), is needed to protect against DNA damage. The specific isoform of p63 that is involved also seems to be the founding member of the p53 family.

Suggested Citation

  • Eun-Kyung Suh & Annie Yang & Arminja Kettenbach & Casimir Bamberger & Ala H. Michaelis & Zhou Zhu & Julia A. Elvin & Roderick T. Bronson & Christopher P. Crum & Frank McKeon, 2006. "p63 protects the female germ line during meiotic arrest," Nature, Nature, vol. 444(7119), pages 624-628, November.
    • Handle: RePEc:nat:nature:v:444:y:2006:i:7119:d:10.1038_nature05337
    DOI: 10.1038/nature05337
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    Cited by:

    1. Fei Sun & Nourhan Nashat Ali & Daniela Londoño-Vásquez & Constantine A. Simintiras & Huanyu Qiao & M. Sofia Ortega & Yuksel Agca & Masashi Takahashi & Rocío M. Rivera & Andrew M. Kelleher & Peter Suto, 2024. "Increased DNA damage in full-grown oocytes is correlated with diminished autophagy activation," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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