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Centriole assembly in Caenorhabditis elegans

Author

Listed:
  • Laurence Pelletier

    (Max Planck Institute of Molecular Cell Biology and Genetics)

  • Eileen O’Toole

    (University of Colorado)

  • Anne Schwager

    (Max Planck Institute of Molecular Cell Biology and Genetics)

  • Anthony A. Hyman

    (Max Planck Institute of Molecular Cell Biology and Genetics)

  • Thomas Müller-Reichert

    (Max Planck Institute of Molecular Cell Biology and Genetics)

Abstract

A cell divided Centrioles, rod-shaped organelles vital to replication in most eukaryotic and animal cells, combine a striking 9-fold symmetric structure and an enigmatic mode of replication. The structure of mature centrioles has been extensively studied, but little is known about how they assemble; and though many centriole proteins have been identified, their functions are obscure. Now centriole assembly in C. elegans has been followed ultrastructurally using electron tomography. Assembly starts with formation of a central tube, proceeds via elongation of the tube and finishes with microtubule singlet assembly onto the tube. A pathway for centriole duplication is proposed where SPD-2, ZYG-1 and SAS proteins act sequentially. Some of these proteins are conserved in humans, suggesting that this mechanism also operates in other centriole-bearing organisms. The central image on the cover shows a microtubule singlet assembling onto a daughter centriole tube.

Suggested Citation

  • Laurence Pelletier & Eileen O’Toole & Anne Schwager & Anthony A. Hyman & Thomas Müller-Reichert, 2006. "Centriole assembly in Caenorhabditis elegans," Nature, Nature, vol. 444(7119), pages 619-623, November.
    • Handle: RePEc:nat:nature:v:444:y:2006:i:7119:d:10.1038_nature05318
    DOI: 10.1038/nature05318
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    Cited by:

    1. Pallavi Panda & Mark S. Ladinsky & David M. Glover, 2024. "9-fold symmetry is not essential for centriole elongation and formation of new centriole-like structures," Nature Communications, Nature, vol. 15(1), pages 1-10, December.

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