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Co-evolution of transcriptional and post-translational cell-cycle regulation

Author

Listed:
  • Lars Juhl Jensen

    (European Molecular Biology Laboratory)

  • Thomas Skøt Jensen

    (Technical University of Denmark)

  • Ulrik de Lichtenberg

    (Technical University of Denmark)

  • Søren Brunak

    (Technical University of Denmark)

  • Peer Bork

    (European Molecular Biology Laboratory
    Max-Delbrück-Centre for Molecular Medicine)

Abstract

Time for change Hundreds of genes are transcribed periodically during the cell cycle. The protein complexes involved are much the same among all eukaryotes, but comparison of large-scale microarray data sets from humans, yeasts and plants shows that many different solutions have evolved for assembling the same molecular machinery at the right point in the cell cycle. Transcriptional and post-translational controls evolve in tandem and change is surprisingly rapid in evolutionary terms — over periods of just a few hundred million years. This implies that even within vertebrates, regulatory systems can differ considerably.

Suggested Citation

  • Lars Juhl Jensen & Thomas Skøt Jensen & Ulrik de Lichtenberg & Søren Brunak & Peer Bork, 2006. "Co-evolution of transcriptional and post-translational cell-cycle regulation," Nature, Nature, vol. 443(7111), pages 594-597, October.
    • Handle: RePEc:nat:nature:v:443:y:2006:i:7111:d:10.1038_nature05186
    DOI: 10.1038/nature05186
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    Cited by:

    1. Kai Wang & Manikandan Narayanan & Hua Zhong & Martin Tompa & Eric E Schadt & Jun Zhu, 2009. "Meta-analysis of Inter-species Liver Co-expression Networks Elucidates Traits Associated with Common Human Diseases," PLOS Computational Biology, Public Library of Science, vol. 5(12), pages 1-16, December.

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