Author
Listed:
- Marc Cruts
(Flanders Interuniversity Institute for Biotechnology
Laboratory of Neurogenetics
University of Antwerp)
- Ilse Gijselinck
(Flanders Interuniversity Institute for Biotechnology
Laboratory of Neurogenetics
University of Antwerp)
- Julie van der Zee
(Flanders Interuniversity Institute for Biotechnology
Laboratory of Neurogenetics
University of Antwerp)
- Sebastiaan Engelborghs
(Laboratory of Neurochemistry and Behavior
University of Antwerp
Middelheim General Hospital)
- Hans Wils
(Flanders Interuniversity Institute for Biotechnology
Laboratory of Neurogenetics
University of Antwerp)
- Daniel Pirici
(Flanders Interuniversity Institute for Biotechnology
Laboratory of Neurogenetics
University of Antwerp)
- Rosa Rademakers
(Flanders Interuniversity Institute for Biotechnology
Laboratory of Neurogenetics
University of Antwerp)
- Rik Vandenberghe
(Department of Neurology)
- Bart Dermaut
(Ghent University Hospital, Ghent University)
- Jean-Jacques Martin
(Laboratory of Neuropathology, Institute Born-Bunge
University of Antwerp)
- Cornelia van Duijn
(Erasmus Medical Center Rotterdam)
- Karin Peeters
(Flanders Interuniversity Institute for Biotechnology
Laboratory of Neurogenetics
University of Antwerp)
- Raf Sciot
(University Hospital Gasthuisberg, Katholieke Universiteit Leuven (KULeuven))
- Patrick Santens
(Ghent University Hospital, Ghent University)
- Tim De Pooter
(Flanders Interuniversity Institute for Biotechnology
Laboratory of Neurogenetics
University of Antwerp)
- Maria Mattheijssens
(Flanders Interuniversity Institute for Biotechnology
Laboratory of Neurogenetics
University of Antwerp)
- Marleen Van den Broeck
(Flanders Interuniversity Institute for Biotechnology
Laboratory of Neurogenetics
University of Antwerp)
- Ivy Cuijt
(Flanders Interuniversity Institute for Biotechnology
Laboratory of Neurogenetics
University of Antwerp)
- Krist'l Vennekens
(Flanders Interuniversity Institute for Biotechnology
Laboratory of Neurogenetics
University of Antwerp)
- Peter P. De Deyn
(Laboratory of Neurochemistry and Behavior
University of Antwerp
Middelheim General Hospital)
- Samir Kumar-Singh
(Flanders Interuniversity Institute for Biotechnology
Laboratory of Neurogenetics
University of Antwerp)
- Christine Van Broeckhoven
(Flanders Interuniversity Institute for Biotechnology
Laboratory of Neurogenetics
University of Antwerp)
Abstract
Dementia-causing mutation Two groups of neuroscientists have discovered that a mutation in the progranulin gene, which encodes a growth factor, can cause frontotemporal dementia (FTD). The condition, the second most common form of dementia among under-65s, impairs memory and personality and may also affect movement. The discovery may help to resolve confusion over the cause of the disease — mutations in a neighbouring gene called microtubule-associated protein tau were shown previously to be associated with some, but not all, cases of FTD.
Suggested Citation
Marc Cruts & Ilse Gijselinck & Julie van der Zee & Sebastiaan Engelborghs & Hans Wils & Daniel Pirici & Rosa Rademakers & Rik Vandenberghe & Bart Dermaut & Jean-Jacques Martin & Cornelia van Duijn & K, 2006.
"Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21,"
Nature, Nature, vol. 442(7105), pages 920-924, August.
Handle:
RePEc:nat:nature:v:442:y:2006:i:7105:d:10.1038_nature05017
DOI: 10.1038/nature05017
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Cited by:
- Hideyuki Takahashi & Sanaea Bhagwagar & Sarah H. Nies & Hongping Ye & Xianlin Han & Marius T. Chiasseu & Guilin Wang & Ian R. Mackenzie & Stephen M. Strittmatter, 2024.
"Reduced progranulin increases tau and α-synuclein inclusions and alters mouse tauopathy phenotypes via glucocerebrosidase,"
Nature Communications, Nature, vol. 15(1), pages 1-23, December.
- Sebastian Boland & Sharan Swarup & Yohannes A. Ambaw & Pedro C. Malia & Ruth C. Richards & Alexander W. Fischer & Shubham Singh & Geetika Aggarwal & Salvatore Spina & Alissa L. Nana & Lea T. Grinberg , 2022.
"Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis,"
Nature Communications, Nature, vol. 13(1), pages 1-13, December.
- Daniel J. Lodge & Hannah B. Elam & Angela M. Boley & Jennifer J. Donegan, 2023.
"Discrete hippocampal projections are differentially regulated by parvalbumin and somatostatin interneurons,"
Nature Communications, Nature, vol. 14(1), pages 1-12, December.
- Yachao He & Ibrahim Kaya & Reza Shariatgorji & Johan Lundkvist & Lars U. Wahlberg & Anna Nilsson & Dejan Mamula & Jan Kehr & Justyna Zareba-Paslawska & Henrik Biverstål & Karima Chergui & Xiaoqun Zhan, 2023.
"Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents,"
Nature Communications, Nature, vol. 14(1), pages 1-22, December.
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