IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v442y2006i7101d10.1038_nature04866.html
   My bibliography  Save this article

ATM stabilizes DNA double-strand-break complexes during V(D)J recombination

Author

Listed:
  • Andrea L. Bredemeyer

    (Washington University School of Medicine)

  • Girdhar G. Sharma

    (Washington University School of Medicine)

  • Ching-Yu Huang

    (Washington University School of Medicine)

  • Beth A. Helmink

    (Washington University School of Medicine)

  • Laura M. Walker

    (Washington University School of Medicine)

  • Katrina C. Khor

    (Washington University School of Medicine)

  • Beth Nuskey

    (University of Pennsylvania School of Medicine)

  • Kathleen E. Sullivan

    (University of Pennsylvania School of Medicine)

  • Tej K. Pandita

    (Washington University School of Medicine)

  • Craig H. Bassing

    (University of Pennsylvania School of Medicine
    Abramson Family Cancer Research Institute)

  • Barry P. Sleckman

    (Washington University School of Medicine)

Abstract

Examination of the role of the ATM protein in oncogenic chromosomal translocations in the disease ataxia telangiectasia finds that ATM is involved directly in stabilizing a complex that occurs when DNA double-strand breaks are made in lymphocyte antigen receptor loci. When the complex is not stabilized, the DNA ends are able to undergo aberrant reactions that can lead to translocations.

Suggested Citation

  • Andrea L. Bredemeyer & Girdhar G. Sharma & Ching-Yu Huang & Beth A. Helmink & Laura M. Walker & Katrina C. Khor & Beth Nuskey & Kathleen E. Sullivan & Tej K. Pandita & Craig H. Bassing & Barry P. Slec, 2006. "ATM stabilizes DNA double-strand-break complexes during V(D)J recombination," Nature, Nature, vol. 442(7101), pages 466-470, July.
    • Handle: RePEc:nat:nature:v:442:y:2006:i:7101:d:10.1038_nature04866
    DOI: 10.1038/nature04866
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature04866
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature04866?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Khalid H. Bhat & Saurabh Priyadarshi & Sarah Naiyer & Xinyan Qu & Hammad Farooq & Eden Kleiman & Jeffery Xu & Xue Lei & Jose F. Cantillo & Robert Wuerffel & Nicole Baumgarth & Jie Liang & Ann J. Feene, 2023. "An Igh distal enhancer modulates antigen receptor diversity by determining locus conformation," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Estelle Vincendeau & Wenming Wei & Xuefei Zhang & Cyril Planchais & Wei Yu & Hélène Lenden-Hasse & Thomas Cokelaer & Juliana Pipoli da Fonseca & Hugo Mouquet & David J. Adams & Frederick W. Alt & Step, 2022. "SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:442:y:2006:i:7101:d:10.1038_nature04866. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.