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A novel class of small RNAs bind to MILI protein in mouse testes

Author

Listed:
  • Alexei Aravin

    (The Rockefeller University
    Cold Spring Harbor Laboratory
    CNRS-UPR 2357, IBMP, 12 rue du Général Zimmer)

  • Dimos Gaidatzis

    (Biozentrum, Universität Basel)

  • Sébastien Pfeffer

    (The Rockefeller University
    Cold Spring Harbor Laboratory
    CNRS-UPR 2357, IBMP, 12 rue du Général Zimmer)

  • Mariana Lagos-Quintana

    (The Rockefeller University)

  • Pablo Landgraf

    (The Rockefeller University)

  • Nicola Iovino

    (The Rockefeller University)

  • Patricia Morris

    (Population Council, The Rockefeller University)

  • Michael J. Brownstein

    (J. Craig Venter Institute, Functional Genomics)

  • Satomi Kuramochi-Miyagawa

    (Graduate School of Frontier Biosciences, Osaka University)

  • Toru Nakano

    (Graduate School of Frontier Biosciences, Osaka University)

  • Minchen Chien

    (Columbia Genome Center, Russ Berrie Pavilion)

  • James J. Russo

    (Columbia Genome Center, Russ Berrie Pavilion)

  • Jingyue Ju

    (Columbia Genome Center, Russ Berrie Pavilion
    Columbia University)

  • Robert Sheridan

    (Computational Biology Center, Memorial Sloan-Kettering Cancer Center)

  • Chris Sander

    (Computational Biology Center, Memorial Sloan-Kettering Cancer Center)

  • Mihaela Zavolan

    (Biozentrum, Universität Basel)

  • Thomas Tuschl

    (The Rockefeller University)

Abstract

A new type of RNAi In RNA interference, small RNAs (siRNAs or miRNAs) act to regulate gene expression. They serve as specificity factors that direct the RISC (RNA-induced silencing) complex to the complementary mRNA targets. A major component of RISC is a protein of the Argonaute family. Two groups have now identified a new class of small RNAs that interact with one Argonaute subfamily, the Piwi class. These testis-specific small RNAs, called 'piRNAs', are slightly longer than the previously described small RNAs. The function of the piRNAs is not yet known, but they might be involved in sperm production.

Suggested Citation

  • Alexei Aravin & Dimos Gaidatzis & Sébastien Pfeffer & Mariana Lagos-Quintana & Pablo Landgraf & Nicola Iovino & Patricia Morris & Michael J. Brownstein & Satomi Kuramochi-Miyagawa & Toru Nakano & Minc, 2006. "A novel class of small RNAs bind to MILI protein in mouse testes," Nature, Nature, vol. 442(7099), pages 203-207, July.
    • Handle: RePEc:nat:nature:v:442:y:2006:i:7099:d:10.1038_nature04916
    DOI: 10.1038/nature04916
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    Citations

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    Cited by:

    1. Xiaolong Lv & Wen Xiao & Yana Lai & Zhaozhen Zhang & Hongdao Zhang & Chen Qiu & Li Hou & Qin Chen & Duanduan Wang & Yun Gao & Yuanyuan Song & Xinjia Shui & Qinghua Chen & Ruixin Qin & Shuang Liang & W, 2023. "The non-redundant functions of PIWI family proteins in gametogenesis in golden hamsters," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Birgit Stallmeyer & Clara Bühlmann & Rytis Stakaitis & Ann-Kristin Dicke & Farah Ghieh & Luisa Meier & Ansgar Zoch & David MacKenzie MacLeod & Johanna Steingröver & Özlem Okutman & Daniela Fietz & Adr, 2024. "Inherited defects of piRNA biogenesis cause transposon de-repression, impaired spermatogenesis, and human male infertility," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    3. Ariane Lismer & Sarah Kimmins, 2023. "Emerging evidence that the mammalian sperm epigenome serves as a template for embryo development," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    4. Yu H. Sun & Ruoqiao Huiyi Wang & Khai Du & Jiang Zhu & Jihong Zheng & Li Huitong Xie & Amanda A. Pereira & Chao Zhang & Emiliano P. Ricci & Xin Zhiguo Li, 2021. "Coupled protein synthesis and ribosome-guided piRNA processing on mRNAs," Nature Communications, Nature, vol. 12(1), pages 1-19, December.
    5. Susanne Bornelöv & Benjamin Czech & Gregory J. Hannon, 2022. "An evolutionarily conserved stop codon enrichment at the 5′ ends of mammalian piRNAs," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    6. Hejin Lai & Ning Feng & Qiwei Zhai, 2023. "Discovery of the major 15–30 nt mammalian small RNAs, their biogenesis and function," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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