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Activity-dependent dynamics and sequestration of proteasomes in dendritic spines

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Listed:
  • Baris Bingol

    (Howard Hughes Medical Institute, California Institute of Technology)

  • Erin M. Schuman

    (Howard Hughes Medical Institute, California Institute of Technology)

Abstract

Proteasomes with nerve The importance of proteasomes in cellular metabolism was recognized by the award of a Nobel prize in 2004 for work on the ubiquitin-proteasome system. Remarkable time-lapse images now provide a glimpse of proteasomes in action in one of their important roles, as modulators of synaptic action in neurons. Significantly the proteasomes are seen to move into the dendritic spines upon depolarization and to become sequestered there. The trafficking of individual synaptic proteins has been seen before, but the observation that a major cell biological machine traffics into spines to change synapses is new, and perhaps counterintuitive. Here the proteasomes seem to be providing specific on-site degradation of proteins in the synapse, rather than routine garbage disposal at a remote site.

Suggested Citation

  • Baris Bingol & Erin M. Schuman, 2006. "Activity-dependent dynamics and sequestration of proteasomes in dendritic spines," Nature, Nature, vol. 441(7097), pages 1144-1148, June.
    • Handle: RePEc:nat:nature:v:441:y:2006:i:7097:d:10.1038_nature04769
    DOI: 10.1038/nature04769
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    Cited by:

    1. Célia Alecki & Javeria Rizwan & Phuong Le & Suleima Jacob-Tomas & Mario Fernandez Comaduran & Morgane Verbrugghe & Jia Ming Stella Xu & Sandra Minotti & James Lynch & Jeetayu Biswas & Tad Wu & Heather, 2024. "Localized molecular chaperone synthesis maintains neuronal dendrite proteostasis," Nature Communications, Nature, vol. 15(1), pages 1-22, December.

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