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Increased cell-to-cell variation in gene expression in ageing mouse heart

Author

Listed:
  • Rumana Bahar

    (Buck Institute for Age Research)

  • Claudia H. Hartmann

    (Institut für Immunologie, Ludwig-Maximilians Universität)

  • Karl A. Rodriguez

    (University of Texas Health Science Center)

  • Ashley D. Denny

    (University of Texas Health Science Center)

  • Rita A. Busuttil

    (Buck Institute for Age Research)

  • Martijn E. T. Dollé

    (National Institute of Public Health and the Environment)

  • R. Brent Calder

    (Buck Institute for Age Research)

  • Gary B. Chisholm

    (University of Texas Health Science Center)

  • Brad H. Pollock

    (University of Texas Health Science Center)

  • Christoph A. Klein

    (Institut für Immunologie, Ludwig-Maximilians Universität)

  • Jan Vijg

    (Buck Institute for Age Research)

Abstract

Old at heart Changes in the control of gene expression due to random damage to the genome have long been considered a possible cause of ageing. A study of heart tissues in young (aged 6 months) and old mice (aged 27 months) provides important data to support that theory. It shows for the first time that there is intrinsic variability in gene expression in cells freshly isolated from mouse heart, and that variability increases with age. Treatment with genotoxic chemicals mimics the effect of ageing. The results point to deregulation of gene expression by chance events as a general mechanism of ageing-related cellular degeneration and death.

Suggested Citation

  • Rumana Bahar & Claudia H. Hartmann & Karl A. Rodriguez & Ashley D. Denny & Rita A. Busuttil & Martijn E. T. Dollé & R. Brent Calder & Gary B. Chisholm & Brad H. Pollock & Christoph A. Klein & Jan Vijg, 2006. "Increased cell-to-cell variation in gene expression in ageing mouse heart," Nature, Nature, vol. 441(7096), pages 1011-1014, June.
    • Handle: RePEc:nat:nature:v:441:y:2006:i:7096:d:10.1038_nature04844
    DOI: 10.1038/nature04844
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    Cited by:

    1. Omid Omrani & Anna Krepelova & Seyed Mohammad Mahdi Rasa & Dovydas Sirvinskas & Jing Lu & Francesco Annunziata & George Garside & Seerat Bajwa & Susanne Reinhardt & Lisa Adam & Sandra Käppel & Nadia D, 2023. "IFNγ-Stat1 axis drives aging-associated loss of intestinal tissue homeostasis and regeneration," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    2. Abhyudai Singh & Mohammad Soltani, 2013. "Quantifying Intrinsic and Extrinsic Variability in Stochastic Gene Expression Models," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-12, December.
    3. Gautam Dey & Gagan D Gupta & Balaji Ramalingam & Mugdha Sathe & Satyajit Mayor & Mukund Thattai, 2014. "Exploiting Cell-To-Cell Variability To Detect Cellular Perturbations," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-10, March.

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