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Control of four stereocentres in a triple cascade organocatalytic reaction

Author

Listed:
  • Dieter Enders

    (RWTH Aachen University)

  • Matthias R. M. Hüttl

    (RWTH Aachen University)

  • Christoph Grondal

    (RWTH Aachen University)

  • Gerhard Raabe

    (RWTH Aachen University)

Abstract

Development of an asymmetric organocatalytic triple cascade able to synthesize tetra-substituted cyclohexene carbaldehydes proceeds through a Michael/Michael/aldol condensation sequence, generating four stereogenic centres with high diastereo- and complete enantiocontrol in good to moderate yields.

Suggested Citation

  • Dieter Enders & Matthias R. M. Hüttl & Christoph Grondal & Gerhard Raabe, 2006. "Control of four stereocentres in a triple cascade organocatalytic reaction," Nature, Nature, vol. 441(7095), pages 861-863, June.
  • Handle: RePEc:nat:nature:v:441:y:2006:i:7095:d:10.1038_nature04820
    DOI: 10.1038/nature04820
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    Cited by:

    1. Shengzhe Ding & Dario Luis Fernandez Ainaga & Min Hu & Boya Qiu & Ushna Khalid & Carmine D’Agostino & Xiaoxia Ou & Ben Spencer & Xiangli Zhong & Yani Peng & Nicole Hondow & Constantinos Theodoropoulos, 2024. "Spatial segregation of catalytic sites within Pd doped H-ZSM-5 for fatty acid hydrodeoxygenation to alkanes," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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