IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v441y2006i7095d10.1038_nature04723.html
   My bibliography  Save this article

Loss of autophagy in the central nervous system causes neurodegeneration in mice

Author

Listed:
  • Masaaki Komatsu

    (Tokyo Metropolitan Institute of Medical Science, Bunkyo-ku
    Juntendo University School of Medicine, Bunkyo-ku)

  • Satoshi Waguri

    (Osaka University Graduate School of Medicine
    Fukushima Medical University School of Medicine)

  • Tomoki Chiba

    (Tokyo Metropolitan Institute of Medical Science, Bunkyo-ku)

  • Shigeo Murata

    (Tokyo Metropolitan Institute of Medical Science, Bunkyo-ku)

  • Jun-ichi Iwata

    (Tokyo Metropolitan Institute of Medical Science, Bunkyo-ku
    Juntendo University School of Medicine, Bunkyo-ku)

  • Isei Tanida

    (Juntendo University School of Medicine, Bunkyo-ku)

  • Takashi Ueno

    (Juntendo University School of Medicine, Bunkyo-ku)

  • Masato Koike

    (Osaka University Graduate School of Medicine)

  • Yasuo Uchiyama

    (Osaka University Graduate School of Medicine)

  • Eiki Kominami

    (Juntendo University School of Medicine, Bunkyo-ku)

  • Keiji Tanaka

    (Tokyo Metropolitan Institute of Medical Science, Bunkyo-ku)

Abstract

A tidy cell is a healthy cell Two papers this week suggest that the process of protein degradation and clearance of cellular components may be more important in maintaining the health of the nervous system than was thought. Both groups show that inhibition of autophagy in mouse brain cells results in neurodegeneration and early death. Autophagy, the protein degradation and recycling of cellular components, is important for the normal growth and development of a cell. The finding that the continual clearance of cellular components is essential for maintaining neuronal health should open up new avenues of research into the nature of neurodegenerative diseases.

Suggested Citation

  • Masaaki Komatsu & Satoshi Waguri & Tomoki Chiba & Shigeo Murata & Jun-ichi Iwata & Isei Tanida & Takashi Ueno & Masato Koike & Yasuo Uchiyama & Eiki Kominami & Keiji Tanaka, 2006. "Loss of autophagy in the central nervous system causes neurodegeneration in mice," Nature, Nature, vol. 441(7095), pages 880-884, June.
    • Handle: RePEc:nat:nature:v:441:y:2006:i:7095:d:10.1038_nature04723
    DOI: 10.1038/nature04723
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature04723
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature04723?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Afshin Saffari & Barbara Brechmann & Cedric Böger & Wardiya Afshar Saber & Hellen Jumo & Dosh Whye & Delaney Wood & Lara Wahlster & Julian E. Alecu & Marvin Ziegler & Marlene Scheffold & Kellen Winden, 2024. "High-content screening identifies a small molecule that restores AP-4-dependent protein trafficking in neuronal models of AP-4-associated hereditary spastic paraplegia," Nature Communications, Nature, vol. 15(1), pages 1-22, December.
    2. Catherine J. Greene & Jenny A. Nguyen & Samuel M. Cheung & Corey R. Arnold & Dale R. Balce & Ya Ting Wang & Adrian Soderholm & Neil McKenna & Devin Aggarwal & Rhiannon I. Campden & Benjamin W. Ewanchu, 2022. "Macrophages disseminate pathogen associated molecular patterns through the direct extracellular release of the soluble content of their phagolysosomes," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Xiaoting Zhou & You-Kyung Lee & Xianting Li & Henry Kim & Carlos Sanchez-Priego & Xian Han & Haiyan Tan & Suiping Zhou & Yingxue Fu & Kerry Purtell & Qian Wang & Gay R. Holstein & Beisha Tang & Junmin, 2024. "Integrated proteomics reveals autophagy landscape and an autophagy receptor controlling PKA-RI complex homeostasis in neurons," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    4. Barbara Baldo & Rana Soylu & Åsa Petersén, 2013. "Maintenance of Basal Levels of Autophagy in Huntington’s Disease Mouse Models Displaying Metabolic Dysfunction," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-15, December.
    5. Alexandra K. Davies & Julian E. Alecu & Marvin Ziegler & Catherine G. Vasilopoulou & Fabrizio Merciai & Hellen Jumo & Wardiya Afshar-Saber & Mustafa Sahin & Darius Ebrahimi-Fakhari & Georg H. H. Borne, 2022. "AP-4-mediated axonal transport controls endocannabinoid production in neurons," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    6. Amy-Jayne Hutchings & Bita Hambrecht & Alexander Veh & Neha Jadhav Giridhar & Abdolhossein Zare & Christina Angerer & Thorben Ohnesorge & Maren Schenke & Bhuvaneish T. Selvaraj & Siddharthan Chandran , 2024. "Plekhg5 controls the unconventional secretion of Sod1 by presynaptic secretory autophagy," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:441:y:2006:i:7095:d:10.1038_nature04723. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.