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Sleep in Drosophila is regulated by adult mushroom bodies

Author

Listed:
  • William J. Joiner

    (Center for Sleep and Respiratory Neurobiology)

  • Amanda Crocker

    (Center for Sleep and Respiratory Neurobiology)

  • Benjamin H. White

    (National Institute of Mental Health)

  • Amita Sehgal

    (Center for Sleep and Respiratory Neurobiology
    University of Pennsylvania Medical School)

Abstract

Sleep regulation The fruitfly Drosophila is well established as a genetic model for the study of sleep. The flies have a behavioural pattern resembling what we call sleep, but the signature EEG changes characteristic of sleep and its stages have not been identified, so it is not possible to say if sleep in flies is a neural process and, if so, what neural substrates are involved. Answering this question is an essential step towards interpreting the mechanisms by which genes influence sleep. Two groups have now tackled the problem, and both identify the structures known as the mushroom bodies as the part of the brain involved in sleep regulation. This discovery brings a neural dimension to sleep in Drosophila and also links sleep to the other known functions of the mushroom bodies — learning and memory.

Suggested Citation

  • William J. Joiner & Amanda Crocker & Benjamin H. White & Amita Sehgal, 2006. "Sleep in Drosophila is regulated by adult mushroom bodies," Nature, Nature, vol. 441(7094), pages 757-760, June.
    • Handle: RePEc:nat:nature:v:441:y:2006:i:7094:d:10.1038_nature04811
    DOI: 10.1038/nature04811
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    Cited by:

    1. Dan Valente & Ilan Golani & Partha P Mitra, 2007. "Analysis of the Trajectory of Drosophila melanogaster in a Circular Open Field Arena," PLOS ONE, Public Library of Science, vol. 2(10), pages 1-9, October.

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