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A dynamic role for the mushroom bodies in promoting sleep in Drosophila

Author

Listed:
  • Jena L. Pitman

    (Northwestern University)

  • Jermaine J. McGill

    (Northwestern University)

  • Kevin P. Keegan

    (Northwestern University)

  • Ravi Allada

    (Northwestern University)

Abstract

Sleep regulation The fruitfly Drosophila is well established as a genetic model for the study of sleep. The flies have a behavioural pattern resembling what we call sleep, but the signature EEG changes characteristic of sleep and its stages have not been identified, so it is not possible to say if sleep in flies is a neural process and, if so, what neural substrates are involved. Answering this question is an essential step towards interpreting the mechanisms by which genes influence sleep. Two groups have now tackled the problem, and both identify the structures known as the mushroom bodies as the part of the brain involved in sleep regulation. This discovery brings a neural dimension to sleep in Drosophila and also links sleep to the other known functions of the mushroom bodies — learning and memory.

Suggested Citation

  • Jena L. Pitman & Jermaine J. McGill & Kevin P. Keegan & Ravi Allada, 2006. "A dynamic role for the mushroom bodies in promoting sleep in Drosophila," Nature, Nature, vol. 441(7094), pages 753-756, June.
    • Handle: RePEc:nat:nature:v:441:y:2006:i:7094:d:10.1038_nature04739
    DOI: 10.1038/nature04739
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    Cited by:

    1. Michaela Joyce & Federica A. Falconio & Laurence Blackhurst & Lucia Prieto-Godino & Alice S. French & Giorgio F. Gilestro, 2024. "Divergent evolution of sleep in Drosophila species," Nature Communications, Nature, vol. 15(1), pages 1-11, December.

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