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Mechanisms of drug inhibition of signalling molecules

Author

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  • Judith S. Sebolt-Leopold

    (Pfizer Global Research and Development, Michigan Laboratories)

  • Jessie M. English

    (Pfizer Research Technology Center)

Abstract

The emergence of tumour-specific, molecularly targeted agents signifies a paradigm shift in cancer therapy, with less reliance on drugs that non-discriminately kill tumour and host cells. Although the diversity of targets giving rise to this new generation of anticancer drugs has expanded, many challenges persist in the design of effective treatment regimens. The complex interplay of signal-transduction pathways further complicates the customization of cancer treatments to target single mechanisms. However, despite uncertainty over precise or dominant mechanisms of action, especially for compounds targeting multiple gene products, emerging agents are producing significant therapeutic advances against a broad range of human cancers.

Suggested Citation

  • Judith S. Sebolt-Leopold & Jessie M. English, 2006. "Mechanisms of drug inhibition of signalling molecules," Nature, Nature, vol. 441(7092), pages 457-462, May.
    • Handle: RePEc:nat:nature:v:441:y:2006:i:7092:d:10.1038_nature04874
    DOI: 10.1038/nature04874
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    Cited by:

    1. Stefan Balabanov & Thomas Wilhelm & Simone Venz & Gunhild Keller & Christian Scharf & Heike Pospisil & Melanie Braig & Christine Barett & Carsten Bokemeyer & Reinhard Walther & Tim H Brümmendorf & And, 2013. "Combination of a Proteomics Approach and Reengineering of Meso Scale Network Models for Prediction of Mode-of-Action for Tyrosine Kinase Inhibitors," PLOS ONE, Public Library of Science, vol. 8(1), pages 1-14, January.

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