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A distal enhancer and an ultraconserved exon are derived from a novel retroposon

Author

Listed:
  • Gill Bejerano

    (University of California Santa Cruz)

  • Craig B. Lowe

    (University of California Santa Cruz)

  • Nadav Ahituv

    (DOE Joint Genome Institute
    Lawrence Berkeley National Laboratory)

  • Bryan King

    (University of California Santa Cruz
    University of California Santa Cruz)

  • Adam Siepel

    (University of California Santa Cruz
    Cornell University)

  • Sofie R. Salama

    (University of California Santa Cruz
    University of California Santa Cruz)

  • Edward M. Rubin

    (DOE Joint Genome Institute
    Lawrence Berkeley National Laboratory)

  • W. James Kent

    (University of California Santa Cruz)

  • David Haussler

    (University of California Santa Cruz
    University of California Santa Cruz)

Abstract

A gene with a past Evidence from vertebrate genome sequences has shown that conserved noncoding regions significantly outnumber coding regions, and that these elements are mostly involved in gene regulation. The origins of these elements are largely unknown, but the availability of the sequence of part of the genome of the Indian coelacanth ‘living fossil’ fish can help track their evolutionary history. One group of these conserved genomic elements has now been identified as originating from a novel short interspersed element (SINE) family of retroposons active 410 million years ago in lobed-finned fishes, and still active today in the coelacanth. Some have acquired function in mammals, with one acting as an enhancer for expression of a neurodevelopmental gene, ISL1, and another as an exon in the mRNA processing gene, PCBP2.

Suggested Citation

  • Gill Bejerano & Craig B. Lowe & Nadav Ahituv & Bryan King & Adam Siepel & Sofie R. Salama & Edward M. Rubin & W. James Kent & David Haussler, 2006. "A distal enhancer and an ultraconserved exon are derived from a novel retroposon," Nature, Nature, vol. 441(7089), pages 87-90, May.
    • Handle: RePEc:nat:nature:v:441:y:2006:i:7089:d:10.1038_nature04696
    DOI: 10.1038/nature04696
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    Cited by:

    1. Noah Dukler & Mehreen R. Mughal & Ritika Ramani & Yi-Fei Huang & Adam Siepel, 2022. "Extreme purifying selection against point mutations in the human genome," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. Tomoyuki Ohno & Taichi Akase & Shunya Kono & Hikaru Kurasawa & Takuto Takashima & Shinya Kaneko & Yasunori Aizawa, 2022. "Biallelic and gene-wide genomic substitution for endogenous intron and retroelement mutagenesis in human cells," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. Kirsten E Eilertson & James G Booth & Carlos D Bustamante, 2012. "SnIPRE: Selection Inference Using a Poisson Random Effects Model," PLOS Computational Biology, Public Library of Science, vol. 8(12), pages 1-14, December.

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