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Analysis of a RanGTP-regulated gradient in mitotic somatic cells

Author

Listed:
  • Petr Kaláb

    (University of California)

  • Arnd Pralle

    (University of California)

  • Ehud Y. Isacoff

    (University of California)

  • Rebecca Heald

    (University of California)

  • Karsten Weis

    (University of California)

Abstract

A fluorescence resonance energy transfer biosensor called Rango enables examination of the Ran–importin-β system in cells. Small changes in RanGTP concentration tip the balance between positive and negative mitotic regulators, thereby promoting spindle assembly and function.

Suggested Citation

  • Petr Kaláb & Arnd Pralle & Ehud Y. Isacoff & Rebecca Heald & Karsten Weis, 2006. "Analysis of a RanGTP-regulated gradient in mitotic somatic cells," Nature, Nature, vol. 440(7084), pages 697-701, March.
  • Handle: RePEc:nat:nature:v:440:y:2006:i:7084:d:10.1038_nature04589
    DOI: 10.1038/nature04589
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    Cited by:

    1. Bernardo Gouveia & Sagar U. Setru & Matthew R. King & Aaron Hamlin & Howard A. Stone & Joshua W. Shaevitz & Sabine Petry, 2023. "Acentrosomal spindles assemble from branching microtubule nucleation near chromosomes in Xenopus laevis egg extract," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Ai Kiyomitsu & Toshiya Nishimura & Shiang Jyi Hwang & Satoshi Ansai & Masato T. Kanemaki & Minoru Tanaka & Tomomi Kiyomitsu, 2024. "Ran-GTP assembles a specialized spindle structure for accurate chromosome segregation in medaka early embryos," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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