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Regulation of cancer cell migration and bone metastasis by RANKL

Author

Listed:
  • D. Holstead Jones

    (IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences
    Department of Medical Biophysics
    University of Toronto
    University of Ontario Institute of Technology)

  • Tomoki Nakashima

    (IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences)

  • Otto H. Sanchez

    (University Health Network
    University of Ontario Institute of Technology)

  • Ivona Kozieradzki

    (IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences
    Department of Medical Biophysics
    University of Toronto)

  • Svetlana V. Komarova

    (McGill University)

  • Ildiko Sarosi

    (Amgen Inc.)

  • Sean Morony

    (Amgen Inc.)

  • Evelyn Rubin

    (Department of Medical Biophysics
    University of Toronto)

  • Renu Sarao

    (IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences)

  • Carlo V. Hojilla

    (University Health Network)

  • Vukoslav Komnenovic

    (IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences)

  • Young-Yun Kong

    (Pohang University of Science and Technology)

  • Martin Schreiber

    (Medical University of Vienna)

  • S. Jeffrey Dixon

    (The University of Western Ontario
    The University of Western Ontario)

  • Stephen M. Sims

    (The University of Western Ontario
    The University of Western Ontario)

  • Rama Khokha

    (Department of Medical Biophysics
    University Health Network)

  • Teiji Wada

    (IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences)

  • Josef M. Penninger

    (IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences
    Department of Medical Biophysics
    University of Toronto)

Abstract

Cancer cells that express the receptor protein RANK migrate to bone tissue where the RANK ligand, RANKL, is found. This contributes to bone metastases and offers a potential therapeutic approach to prevent cancer metastases.

Suggested Citation

  • D. Holstead Jones & Tomoki Nakashima & Otto H. Sanchez & Ivona Kozieradzki & Svetlana V. Komarova & Ildiko Sarosi & Sean Morony & Evelyn Rubin & Renu Sarao & Carlo V. Hojilla & Vukoslav Komnenovic & Y, 2006. "Regulation of cancer cell migration and bone metastasis by RANKL," Nature, Nature, vol. 440(7084), pages 692-696, March.
    • Handle: RePEc:nat:nature:v:440:y:2006:i:7084:d:10.1038_nature04524
    DOI: 10.1038/nature04524
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    Cited by:

    1. Dane Huang & Chao Zhao & Ruyue Li & Bingyi Chen & Yuting Zhang & Zhejun Sun & Junkang Wei & Huihao Zhou & Qiong Gu & Jun Xu, 2022. "Identification of a binding site on soluble RANKL that can be targeted to inhibit soluble RANK-RANKL interactions and treat osteoporosis," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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