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ClC chloride channels viewed through a transporter lens

Author

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  • Christopher Miller

    (Howard Hughes Medical Institute, Brandeis University)

Abstract

Since its discovery, the ClC family of chloride channels has presented biophysicists with unexpected behaviours and unusual surprises. The latest of these is the realization that not only does the family feature genuine chloride channels, it also includes proton-coupled chloride transporters, which move chloride ions and protons across the membrane in opposite directions. The crystal structure of such a transporter serves as a useful platform for understanding ClC channels, and features of chloride/proton exchange-transport may provide a key for comprehending voltage-dependent gating of the channels.

Suggested Citation

  • Christopher Miller, 2006. "ClC chloride channels viewed through a transporter lens," Nature, Nature, vol. 440(7083), pages 484-489, March.
    • Handle: RePEc:nat:nature:v:440:y:2006:i:7083:d:10.1038_nature04713
    DOI: 10.1038/nature04713
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    Cited by:

    1. Yangzhuoqun Wan & Shuangshuang Guo & Wenxuan Zhen & Lizhen Xu & Xiaoying Chen & Fangyue Liu & Yi Shen & Shuangshuang Liu & Lidan Hu & Xinyan Wang & Fengcan Ye & Qinrui Wang & Han Wen & Fan Yang, 2024. "Structural basis of adenine nucleotides regulation and neurodegenerative pathology in ClC-3 exchanger," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Keri A McKiernan & Anna K Koster & Merritt Maduke & Vijay S Pande, 2020. "Dynamical model of the CLC-2 ion channel reveals conformational changes associated with selectivity-filter gating," PLOS Computational Biology, Public Library of Science, vol. 16(3), pages 1-24, March.
    3. Sivamathini Rajappa & Pannaga Krishnamurthy & Hua Huang & Dejie Yu & Jiří Friml & Jian Xu & Prakash P. Kumar, 2024. "The translocation of a chloride channel from the Golgi to the plasma membrane helps plants adapt to salt stress," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    4. Tao Ma & Lei Wang & Anping Chai & Chao Liu & Wenqiang Cui & Shuguang Yuan & Shannon Wing Ngor Au & Liang Sun & Xiaokang Zhang & Zhenzhen Zhang & Jianping Lu & Yuanzhu Gao & Peiyi Wang & Zhifang Li & Y, 2023. "Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    5. Lilia Leisle & Kin Lam & Sepehr Dehghani-Ghahnaviyeh & Eva Fortea & Jason D. Galpin & Christopher A. Ahern & Emad Tajkhorshid & Alessio Accardi, 2022. "Backbone amides are determinants of Cl− selectivity in CLC ion channels," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

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