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RETRACTED ARTICLE: A specific amyloid-β protein assembly in the brain impairs memory

Author

Listed:
  • Sylvain Lesné

    (Departments of Neurology)

  • Ming Teng Koh

    (Johns Hopkins University)

  • Linda Kotilinek

    (Departments of Neurology)

  • Rakez Kayed

    (University of California)

  • Charles G. Glabe

    (University of California)

  • Austin Yang

    (University of Southern California)

  • Michela Gallagher

    (Johns Hopkins University)

  • Karen H. Ashe

    (Departments of Neurology
    Neuroscience
    University of Minnesota Medical School
    Minneapolis VA Medical Center)

Abstract

Early Warning Of Alzheimer's Poor memory function has been noted in individuals that developed Alzheimer's disease up to 15 years before the eventual diagnosis of the condition. Experiments in a mouse model for the disease have now tracked down a possible cause for this early symptom: the extracellular accumulation of a soluble amyloid-β peptide assembly, dubbed Aβ*. When Aβ* is isolated from these mice and injected into rats, the rats also experience temporary memory deterioration independent of plaque formation or neuronal loss, the classic hallmarks of Alzheimer's. This work points to Aβ* as a potential diagnostic, and raises the possibility that by targeting it early it may be possible to prevent or delay the permanent changes characteristic of the later stages of the disease.

Suggested Citation

  • Sylvain Lesné & Ming Teng Koh & Linda Kotilinek & Rakez Kayed & Charles G. Glabe & Austin Yang & Michela Gallagher & Karen H. Ashe, 2006. "RETRACTED ARTICLE: A specific amyloid-β protein assembly in the brain impairs memory," Nature, Nature, vol. 440(7082), pages 352-357, March.
    • Handle: RePEc:nat:nature:v:440:y:2006:i:7082:d:10.1038_nature04533
    DOI: 10.1038/nature04533
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    Cited by:

    1. Massih Khorvash & Nick Blinov & Carol Ladner-Keay & Jie Lu & Judith M Silverman & Ebrima Gibbs & Yu Tian Wang & Andriy Kovalenko & David Wishart & Neil R Cashman, 2020. "Molecular interactions between monoclonal oligomer-specific antibody 5E3 and its amyloid beta cognates," PLOS ONE, Public Library of Science, vol. 15(5), pages 1-35, May.
    2. Xiaohang Li & Jin Cui & Yang Yu & Wei Li & Yujun Hou & Xin Wang & Dapeng Qin & Cun Zhao & Xinsheng Yao & Jian Zhao & Gang Pei, 2016. "Traditional Chinese Nootropic Medicine Radix Polygalae and Its Active Constituent Onjisaponin B Reduce β-Amyloid Production and Improve Cognitive Impairments," PLOS ONE, Public Library of Science, vol. 11(3), pages 1-19, March.
    3. Begoña López-Arias & Enrique Turiégano & Ignacio Monedero & Inmaculada Canal & Laura Torroja, 2017. "Presynaptic Aβ40 prevents synapse addition in the adult Drosophila neuromuscular junction," PLOS ONE, Public Library of Science, vol. 12(5), pages 1-22, May.
    4. Maher A Dayeh & George Livadiotis & Saber Elaydi, 2018. "A discrete mathematical model for the aggregation of β-Amyloid," PLOS ONE, Public Library of Science, vol. 13(5), pages 1-13, May.

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