IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v439y2006i7079d10.1038_nature04509.html
   My bibliography  Save this article

Fast vesicle reloading and a large pool sustain high bandwidth transmission at a central synapse

Author

Listed:
  • Chiara Saviane

    (University College London)

  • R. Angus Silver

    (University College London)

Abstract

What limits the rate at which sensory information can be transmitted across synaptic connections in the brain? High-frequency signalling is restricted to brief bursts at many central excitatory synapses1,2, whereas graded ribbon-type synapses can sustain release3 and transmit information4 at high rates. Here we investigate transmission at the cerebellar mossy fibre terminal, which can fire at over 200 Hz for sustained periods in vivo5, yet makes few synaptic contacts onto individual granule cells6. We show that connections between mossy fibres and granule cells can sustain high-frequency signalling at physiological temperature. We use fluctuation analysis7 and pharmacological block of desensitization to identify the quantal determinants of short-term plasticity and combine these with a short-term plasticity model and cumulative excitatory postsynaptic current analysis to quantify the determinants of sustained high-frequency transmission. We show that release is maintained at each release site by rapid reloading of release-ready vesicles from an unusually large releasable pool of vesicles8 (∼300 per site). Our results establish that sustained vesicular release at high rates is not restricted to graded ribbon-type synapses and that mossy fibres are well suited for transmitting broad-bandwidth rate-coded information to the input layer of the cerebellar cortex.

Suggested Citation

  • Chiara Saviane & R. Angus Silver, 2006. "Fast vesicle reloading and a large pool sustain high bandwidth transmission at a central synapse," Nature, Nature, vol. 439(7079), pages 983-987, February.
    • Handle: RePEc:nat:nature:v:439:y:2006:i:7079:d:10.1038_nature04509
    DOI: 10.1038/nature04509
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature04509
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature04509?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. A. Barri & M. T. Wiechert & M. Jazayeri & D. A. DiGregorio, 2022. "Synaptic basis of a sub-second representation of time in a neural circuit model," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. Shyam Diwakar & Paola Lombardo & Sergio Solinas & Giovanni Naldi & Egidio D'Angelo, 2011. "Local Field Potential Modeling Predicts Dense Activation in Cerebellar Granule Cells Clusters under LTP and LTD Control," PLOS ONE, Public Library of Science, vol. 6(7), pages 1-13, July.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:439:y:2006:i:7079:d:10.1038_nature04509. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.