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Generation of a functional mammary gland from a single stem cell

Author

Listed:
  • Mark Shackleton

    (The Walter and Eliza Hall Institute of Medical Research
    Royal Melbourne Hospital)

  • François Vaillant

    (The Walter and Eliza Hall Institute of Medical Research
    Royal Melbourne Hospital)

  • Kaylene J. Simpson

    (The University of Melbourne
    Harvard Medical School)

  • John Stingl

    (British Columbia Cancer Agency
    Stem Cell Technologies Inc.)

  • Gordon K. Smyth

    (The Walter and Eliza Hall Institute of Medical Research)

  • Marie-Liesse Asselin-Labat

    (The Walter and Eliza Hall Institute of Medical Research
    Royal Melbourne Hospital)

  • Li Wu

    (The Walter and Eliza Hall Institute of Medical Research)

  • Geoffrey J. Lindeman

    (The Walter and Eliza Hall Institute of Medical Research
    Royal Melbourne Hospital)

  • Jane E. Visvader

    (The Walter and Eliza Hall Institute of Medical Research
    Royal Melbourne Hospital)

Abstract

Mammary stem cells The existence of mammary stem cells has been inferred from genetic analysis of human breast tissue, and from the fact that mouse mammary gland can regenerate from tissue fragments. Two groups now report the isolation of mammary stem cells from mice. Shackleton et al. use a technique based on the introduction of a marker for stem-cell function. A single cell from this population then showed its potency by regenerating an entire mammary gland in vivo. This population of cells is expanded in a pre-malignant mammary tumour model, providing support for the concept of a mammary cancer stem cell. In a paper published online, Stingl et al. report the use of a powerful limiting dilution transplant procedure to purify to near homogeneity a rare subset of adult mouse mammary cells that can individually regenerate an entire mammary gland within six weeks.

Suggested Citation

  • Mark Shackleton & François Vaillant & Kaylene J. Simpson & John Stingl & Gordon K. Smyth & Marie-Liesse Asselin-Labat & Li Wu & Geoffrey J. Lindeman & Jane E. Visvader, 2006. "Generation of a functional mammary gland from a single stem cell," Nature, Nature, vol. 439(7072), pages 84-88, January.
    • Handle: RePEc:nat:nature:v:439:y:2006:i:7072:d:10.1038_nature04372
    DOI: 10.1038/nature04372
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    Cited by:

    1. Ana Sofia Rocha & Alejandro Collado-Solé & Osvaldo Graña-Castro & Jaime Redondo-Pedraza & Gonzalo Soria-Alcaide & Alex Cordero & Patricia G. Santamaría & Eva González-Suárez, 2023. "Luminal Rank loss decreases cell fitness leading to basal cell bipotency in parous mammary glands," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Huiru Bai & Xiaoqin Liu & Meizhen Lin & Yuan Meng & Ruolan Tang & Yajing Guo & Nan Li & Michael F. Clarke & Shang Cai, 2024. "Progressive senescence programs induce intrinsic vulnerability to aging-related female breast cancer," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    3. Xing Yang & Haibo Xu & Xu Yang & Hui Wang & Li Zou & Qin Yang & Xiaopeng Qi & Li Li & Hongxia Duan & Xiyun Yan & Nai Yang Fu & Jing Tan & Zongliu Hou & Baowei Jiao, 2024. "Mcam inhibits macrophage-mediated development of mammary gland through non-canonical Wnt signaling," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    4. Elena Spina & Julia Simundza & Angela Incassati & Anupama Chandramouli & Matthias C. Kugler & Ziyan Lin & Alireza Khodadadi-Jamayran & Christine J. Watson & Pamela Cowin, 2022. "Gpr125 is a unifying hallmark of multiple mammary progenitors coupled to tumor latency," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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