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Histone H3 serine 10 phosphorylation by Aurora B causes HP1 dissociation from heterochromatin

Author

Listed:
  • Toru Hirota

    (Dr. Bohrgasse 7
    Cancer Institute, Japanese Foundation for Cancer Research)

  • Jesse J. Lipp

    (Dr. Bohrgasse 7)

  • Ban-Hock Toh

    (Monash University Medical School)

  • Jan-Michael Peters

    (Dr. Bohrgasse 7)

Abstract

Histones are subject to numerous post-translational modifications1. Some of these ‘epigenetic’ marks recruit proteins that modulate chromatin structure. For example, heterochromatin protein 1 (HP1) binds to histone H3 when its lysine 9 residue has been tri-methylated by the methyltransferase Suv39h (refs 2–6). During mitosis, H3 is also phosphorylated by the kinase Aurora B 7. Although H3 phosphorylation is a hallmark of mitosis, its function remains mysterious. It has been proposed that histone phosphorylation controls the binding of proteins to chromatin8, but any such mechanisms are unknown. Here we show that antibodies against mitotic chromosomal antigens that are associated with human autoimmune diseases9 specifically recognize H3 molecules that are modified by both tri-methylation of lysine 9 and phosphorylation of serine 10 (H3K9me3S10ph). The generation of H3K9me3S10ph depends on Suv39h and Aurora B, and occurs at pericentric heterochromatin during mitosis in different eukaryotes. Most HP1 typically dissociates from chromosomes during mitosis10,11,12, but if phosphorylation of H3 serine 10 is inhibited, HP1 remains chromosome-bound throughout mitosis. H3 phosphorylation by Aurora B is therefore part of a ‘methyl/phos switch’ mechanism8 that displaces HP1 and perhaps other proteins from mitotic heterochromatin.

Suggested Citation

  • Toru Hirota & Jesse J. Lipp & Ban-Hock Toh & Jan-Michael Peters, 2005. "Histone H3 serine 10 phosphorylation by Aurora B causes HP1 dissociation from heterochromatin," Nature, Nature, vol. 438(7071), pages 1176-1180, December.
    • Handle: RePEc:nat:nature:v:438:y:2005:i:7071:d:10.1038_nature04254
    DOI: 10.1038/nature04254
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    Cited by:

    1. Rebecca J. Harris & Maninder Heer & Mark D. Levasseur & Tyrell N. Cartwright & Bethany Weston & Jennifer L. Mitchell & Jonathan M. Coxhead & Luke Gaughan & Lisa Prendergast & Daniel Rico & Jonathan M., 2023. "Release of Histone H3K4-reading transcription factors from chromosomes in mitosis is independent of adjacent H3 phosphorylation," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Judith H. I. Haarhuis & Robin H. Weide & Vincent A. Blomen & Koen D. Flach & Hans Teunissen & Laureen Willems & Thijn R. Brummelkamp & Benjamin D. Rowland & Elzo Wit, 2022. "A Mediator-cohesin axis controls heterochromatin domain formation," Nature Communications, Nature, vol. 13(1), pages 1-10, December.

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