IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v438y2005i7070d10.1038_nature04479.html
   My bibliography  Save this article

Endothelial cells and VEGF in vascular development

Author

Listed:
  • Leigh Coultas

    (The Hospital for Sick Children)

  • Kallayanee Chawengsaksophak

    (The Hospital for Sick Children)

  • Janet Rossant

    (The Hospital for Sick Children)

Abstract

The intricate patterning processes that establish the complex vascular system during development depend on a combination of intrinsic pre-patterning and extrinsic responses to environmental parameters. Mutational studies in mice and fish have shown that the vascular system is highly sensitive to genetic disruption and have identified potential targets for therapeutic interventions. New insights into non-vascular roles of vascular endothelial growth factor and the requirement for endothelial cells in adult organs and stem-cell niches highlight possible side effects of anti-angiogenic therapy and the need for new targets.

Suggested Citation

  • Leigh Coultas & Kallayanee Chawengsaksophak & Janet Rossant, 2005. "Endothelial cells and VEGF in vascular development," Nature, Nature, vol. 438(7070), pages 937-945, December.
    • Handle: RePEc:nat:nature:v:438:y:2005:i:7070:d:10.1038_nature04479
    DOI: 10.1038/nature04479
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature04479
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature04479?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Fuchun Yang & Shiva Kalantari & Banzhan Ruan & Shaogang Sun & Zhaoqun Bian & Jun-Lin Guan, 2023. "Autophagy inhibition prevents lymphatic malformation progression to lymphangiosarcoma by decreasing osteopontin and Stat3 signaling," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:438:y:2005:i:7070:d:10.1038_nature04479. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.