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BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain

Author

Listed:
  • Jeffrey A. M. Coull

    (Centre de Recherche Université Laval Robert-Giffard
    McGill University
    McGill University)

  • Simon Beggs

    (The Hospital for Sick Children)

  • Dominic Boudreau

    (Centre de Recherche Université Laval Robert-Giffard)

  • Dominick Boivin

    (Centre de Recherche Université Laval Robert-Giffard)

  • Makoto Tsuda

    (The Hospital for Sick Children
    Kyushu University)

  • Kazuhide Inoue

    (Kyushu University)

  • Claude Gravel

    (Centre de recherche Université Laval Robert-Giffard
    Université Laval)

  • Michael W. Salter

    (The Hospital for Sick Children)

  • Yves De Koninck

    (Centre de Recherche Université Laval Robert-Giffard
    McGill University
    McGill University
    Université Laval)

Abstract

GABA is a pain Neuropathic pain, one of the most debilitating of all pain states, often arises from injury to a peripheral nerve that depends on activation of a specific cell type known as microglia. This prompts the question, how do the microglia signal to spinal pain neurons? Coull et al. have now identified the biophysical mechanism by which microglia, activated by ATP, cause hyperexcitability of spinal neurons. The microglia release brain-derived neurotrophic factor, which alters chloride ion distribution across the plasma membrane of neurons in lamina I of the spinal cord. This results in the neurotransmitter, GABA, activating (rather than inhibiting) these cells that form part of a major pathway that signals pain. A collection of recent reprints on neuropathic pain, taken from Nature Publishing Group journals is, now available online via tinyurl.com/dzw86.

Suggested Citation

  • Jeffrey A. M. Coull & Simon Beggs & Dominic Boudreau & Dominick Boivin & Makoto Tsuda & Kazuhide Inoue & Claude Gravel & Michael W. Salter & Yves De Koninck, 2005. "BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain," Nature, Nature, vol. 438(7070), pages 1017-1021, December.
    • Handle: RePEc:nat:nature:v:438:y:2005:i:7070:d:10.1038_nature04223
    DOI: 10.1038/nature04223
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    Cited by:

    1. Girolamo Di Maio & Ines Villano & Ciro Rosario Ilardi & Antonietta Messina & Vincenzo Monda & Ashlei Clara Iodice & Chiara Porro & Maria Antonietta Panaro & Sergio Chieffi & Giovanni Messina & Marcell, 2023. "Mechanisms of Transmission and Processing of Pain: A Narrative Review," IJERPH, MDPI, vol. 20(4), pages 1-19, February.

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