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A mutation accumulation assay reveals a broad capacity for rapid evolution of gene expression

Author

Listed:
  • Scott A. Rifkin

    (Yale University
    Yale University School of Medicine
    Harvard University)

  • David Houle

    (Florida State University)

  • Junhyong Kim

    (University of Pennsylvania, 203 Goddard Laboratories)

  • Kevin P. White

    (Yale University
    Yale University School of Medicine)

Abstract

Evolve in haste... An experiment in twelve different strains of Drosophila suggests that naturally occurring mutations generate a large amount of gene expression variation at a surprisingly rapid rate. After only 200 generations of allowing natural mutations (with weak or no ill effects) to accumulate, gene expression evolution was detected in 40% of all genes. That variation has the potential to fuel evolution, yet comparison of the observed evolutionary rates with differences between species suggests that natural variation is constrained by physical, developmental, or some other factors.

Suggested Citation

  • Scott A. Rifkin & David Houle & Junhyong Kim & Kevin P. White, 2005. "A mutation accumulation assay reveals a broad capacity for rapid evolution of gene expression," Nature, Nature, vol. 438(7065), pages 220-223, November.
    • Handle: RePEc:nat:nature:v:438:y:2005:i:7065:d:10.1038_nature04114
    DOI: 10.1038/nature04114
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    Cited by:

    1. Gaotian Zhang & Nicole M. Roberto & Daehan Lee & Steffen R. Hahnel & Erik C. Andersen, 2022. "The impact of species-wide gene expression variation on Caenorhabditis elegans complex traits," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Siewert Elizabeth A & Kechris Katerina J, 2009. "Prediction of Motifs Based on a Repeated-Measures Model for Integrating Cross-Species Sequence and Expression Data," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 8(1), pages 1-36, September.

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