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Adaptive immune responses in acute and chronic hepatitis C virus infection

Author

Listed:
  • David G. Bowen

    (Center for Vaccines and Immunity, Columbus Children's Research Institute)

  • Christopher M. Walker

    (Center for Vaccines and Immunity, Columbus Children's Research Institute
    College of Medicine and Public Health, Ohio State University)

Abstract

The hepatitis C virus (HCV) persists in the majority of infected individuals and is a significant cause of human illness and death globally. Recent studies have yielded important insights into immunity to HCV, in particular revealing the central role of T cells in viral control and clearance. Other key features of adaptive immune responses remain obscure, including mechanisms by which T cells control HCV replication, the role of antibodies in conferring protection and how cellular and humoral immunity are subverted in persistent infection.

Suggested Citation

  • David G. Bowen & Christopher M. Walker, 2005. "Adaptive immune responses in acute and chronic hepatitis C virus infection," Nature, Nature, vol. 436(7053), pages 946-952, August.
    • Handle: RePEc:nat:nature:v:436:y:2005:i:7053:d:10.1038_nature04079
    DOI: 10.1038/nature04079
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    Cited by:

    1. Anne Burgevin & Loredana Saveanu & Yohan Kim & Émilie Barilleau & Maya Kotturi & Alessandro Sette & Peter van Endert & Bjoern Peters, 2008. "A Detailed Analysis of the Murine TAP Transporter Substrate Specificity," PLOS ONE, Public Library of Science, vol. 3(6), pages 1-8, June.
    2. Kieran English & Rain Kwan & Lauren E. Holz & Claire McGuffog & Jelte M. M. Krol & Daryan Kempe & Tsuneyasu Kaisho & William R. Heath & Leszek Lisowski & Maté Biro & Geoffrey W. McCaughan & David G. B, 2024. "A hepatic network of dendritic cells mediates CD4 T cell help outside lymphoid organs," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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