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ERM is required for transcriptional control of the spermatogonial stem cell niche

Author

Listed:
  • Chen Chen

    (Department of Pathology and Immunology)

  • Wenjun Ouyang

    (Genentech)

  • Vadim Grigura

    (Department of Pathology and Immunology)

  • Qing Zhou

    (Washington State University)

  • Kay Carnes

    (University of Illinois at Urbana–Champaign)

  • Hyunjung Lim

    (Washington University School of Medicine)

  • Guang-Quan Zhao

    (University of Texas Southwestern Medical School)

  • Silvia Arber

    (University of Basel
    Friedrich Miescher Institute)

  • Natasza Kurpios

    (McMaster University)

  • Theresa L. Murphy

    (Department of Pathology and Immunology)

  • Alec M. Cheng

    (Genentech)

  • John A. Hassell

    (McMaster University)

  • Varadaraj Chandrashekar

    (Southern Illinois University School of Medicine)

  • Marie-Claude Hofmann

    (The University of Dayton)

  • Rex A. Hess

    (University of Illinois at Urbana–Champaign)

  • Kenneth M. Murphy

    (Department of Pathology and Immunology
    Howard Hughes Medical Institute)

Abstract

Division of spermatogonial stem cells1 produces daughter cells that either maintain their stem cell identity or undergo differentiation to form mature sperm. The Sertoli cell, the only somatic cell within seminiferous tubules, provides the stem cell niche through physical support and expression of surface proteins and soluble factors2,3. Here we show that the Ets related molecule4 (ERM) is expressed exclusively within Sertoli cells in the testis and is required for spermatogonial stem cell self-renewal. Mice with targeted disruption of ERM have a loss of maintenance of spermatogonial stem cell self-renewal without a block in normal spermatogenic differentiation and thus have progressive germ-cell depletion and a Sertoli-cell-only syndrome. Microarray analysis of primary Sertoli cells from ERM-deficient mice showed alterations in secreted factors known to regulate the haematopoietic stem cell niche. These results identify a new function for the Ets family transcription factors in spermatogenesis and provide an example of transcriptional control of a vertebrate stem cell niche.

Suggested Citation

  • Chen Chen & Wenjun Ouyang & Vadim Grigura & Qing Zhou & Kay Carnes & Hyunjung Lim & Guang-Quan Zhao & Silvia Arber & Natasza Kurpios & Theresa L. Murphy & Alec M. Cheng & John A. Hassell & Varadaraj C, 2005. "ERM is required for transcriptional control of the spermatogonial stem cell niche," Nature, Nature, vol. 436(7053), pages 1030-1034, August.
    • Handle: RePEc:nat:nature:v:436:y:2005:i:7053:d:10.1038_nature03894
    DOI: 10.1038/nature03894
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    Cited by:

    1. Jiexiang Zhao & Ping Lu & Cong Wan & Yaping Huang & Manman Cui & Xinyan Yang & Yuqiong Hu & Yi Zheng & Ji Dong & Mei Wang & Shu Zhang & Zhaoting Liu & Shuhui Bian & Xiaoman Wang & Rui Wang & Shaofang , 2021. "Cell-fate transition and determination analysis of mouse male germ cells throughout development," Nature Communications, Nature, vol. 12(1), pages 1-20, December.
    2. Andreas Lackner & Michael Müller & Magdalena Gamperl & Delyana Stoeva & Olivia Langmann & Henrieta Papuchova & Elisabeth Roitinger & Gerhard Dürnberger & Richard Imre & Karl Mechtler & Paulina A. Lato, 2023. "The Fgf/Erf/NCoR1/2 repressive axis controls trophoblast cell fate," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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