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X-ray structure of a tetranucleosome and its implications for the chromatin fibre

Author

Listed:
  • Thomas Schalch

    (Institute for Molecular Biology and Biophysics, ETH–Hönggerberg)

  • Sylwia Duda

    (Institute for Molecular Biology and Biophysics, ETH–Hönggerberg)

  • David F. Sargent

    (Institute for Molecular Biology and Biophysics, ETH–Hönggerberg)

  • Timothy J. Richmond

    (Institute for Molecular Biology and Biophysics, ETH–Hönggerberg)

Abstract

Chromatin organization The fundamental level of DNA organization was revealed in 1997 with the determination of the nucleosome core structure. The crystal structure of a tetranucleosome has now been determined at 9Å resolution, showing how nucleosomes are arranged at the next level up, in the chromosomes that are the substrate for DNA replication. The nucleosomes form a two-start helix, and their geometry in the chromatin matrix is best described by the ‘crossed-linker’ model.

Suggested Citation

  • Thomas Schalch & Sylwia Duda & David F. Sargent & Timothy J. Richmond, 2005. "X-ray structure of a tetranucleosome and its implications for the chromatin fibre," Nature, Nature, vol. 436(7047), pages 138-141, July.
    • Handle: RePEc:nat:nature:v:436:y:2005:i:7047:d:10.1038_nature03686
    DOI: 10.1038/nature03686
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    Citations

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    Cited by:

    1. Ji-Ping Wang & Yvonne Fondufe-Mittendorf & Liqun Xi & Guei-Feng Tsai & Eran Segal & Jonathan Widom, 2008. "Preferentially Quantized Linker DNA Lengths in Saccharomyces cerevisiae," PLOS Computational Biology, Public Library of Science, vol. 4(9), pages 1-10, September.
    2. Francesca Maggioni & Marida Bertocchi & Ettore Mosca & Rolland Reinbold & Ileana Zucchi, 2013. "Modeling chromatin fibre folding for human embryonic stem cells," Working Papers (2013-) 1301_qum, University of Bergamo, Department of Management, Economics and Quantitative Methods.
    3. Uwe Schneider & Fabiano Vasi & Jürgen Besserer, 2016. "The Impact of the Geometrical Structure of the DNA on Parameters of the Track-Event Theory for Radiation Induced Cell Kill," PLOS ONE, Public Library of Science, vol. 11(10), pages 1-13, October.
    4. Shuxiang Li & Tiejun Wei & Anna R. Panchenko, 2023. "Histone variant H2A.Z modulates nucleosome dynamics to promote DNA accessibility," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    5. Harsh Nagpal & Ahmad Ali-Ahmad & Yasuhiro Hirano & Wei Cai & Mario Halic & Tatsuo Fukagawa & Nikolina Sekulić & Beat Fierz, 2023. "CENP-A and CENP-B collaborate to create an open centromeric chromatin state," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    6. Meng Zhang & César Díaz-Celis & Jianfang Liu & Jinhui Tao & Paul D. Ashby & Carlos Bustamante & Gang Ren, 2024. "Angle between DNA linker and nucleosome core particle regulates array compaction revealed by individual-particle cryo-electron tomography," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    7. Rina Hirano & Haruhiko Ehara & Tomoya Kujirai & Tamami Uejima & Yoshimasa Takizawa & Shun-ichi Sekine & Hitoshi Kurumizaka, 2022. "Structural basis of RNA polymerase II transcription on the chromatosome containing linker histone H1," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    8. Zhen Hou & Frank Nightingale & Yanan Zhu & Craig MacGregor-Chatwin & Peijun Zhang, 2023. "Structure of native chromatin fibres revealed by Cryo-ET in situ," Nature Communications, Nature, vol. 14(1), pages 1-7, December.

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