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In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment

Author

Listed:
  • Dorothy A. Sipkins

    (Wellman Center for Photomedicine
    Massachusetts General Hospital, Harvard Medical School
    Massachusetts General Hospital and Dana-Farber Cancer Institute, Harvard Medical School)

  • Xunbin Wei

    (Wellman Center for Photomedicine)

  • Juwell W. Wu

    (Wellman Center for Photomedicine)

  • Judith M. Runnels

    (Wellman Center for Photomedicine)

  • Daniel Côté

    (Wellman Center for Photomedicine)

  • Terry K. Means

    (Massachusetts General Hospital East, Harvard Medical School)

  • Andrew D. Luster

    (Massachusetts General Hospital East, Harvard Medical School)

  • David T. Scadden

    (Massachusetts General Hospital, Harvard Medical School
    Massachusetts General Hospital and Dana-Farber Cancer Institute, Harvard Medical School
    Harvard University)

  • Charles P. Lin

    (Wellman Center for Photomedicine)

Abstract

Comfortable cells The power of the latest microscopy techniques is demonstrated in a study of the vascular microenvironment in the bone marrow of mice. Confocal microscopy optimized for live animal imaging reveals that the tissue divides into discrete areas marked out by specialized endothelium. Molecules expressed in these domains mediate highly localized homing of the stem progenitor cells and lymphocytes needed for normal function of the bone marrow. But cancer cells — from an acute lymphoblastic leukaemia cell line, for instance — can also follow the trail to a welcoming microdomian. The vascular structures that create these inner spaces might therefore be potential targets for drugs designed to treat metastatic cancers.

Suggested Citation

  • Dorothy A. Sipkins & Xunbin Wei & Juwell W. Wu & Judith M. Runnels & Daniel Côté & Terry K. Means & Andrew D. Luster & David T. Scadden & Charles P. Lin, 2005. "In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment," Nature, Nature, vol. 435(7044), pages 969-973, June.
    • Handle: RePEc:nat:nature:v:435:y:2005:i:7044:d:10.1038_nature03703
    DOI: 10.1038/nature03703
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    Cited by:

    1. Jialiang S. Wang & Tushar Kamath & Courtney M. Mazur & Fatemeh Mirzamohammadi & Daniel Rotter & Hironori Hojo & Christian D. Castro & Nicha Tokavanich & Rushi Patel & Nicolas Govea & Tetsuya Enishi & , 2021. "Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin," Nature Communications, Nature, vol. 12(1), pages 1-20, December.

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