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Spatial bistability of Dpp–receptor interactions during Drosophila dorsal–ventral patterning

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  • Yu-Chiun Wang

    (Department of Organismal Biology and Anatomy and)

  • Edwin L. Ferguson

    (Department of Organismal Biology and Anatomy and
    University of Chicago)

Abstract

In many developmental contexts, a locally produced morphogen specifies positional information by forming a concentration gradient over a field of cells1. However, during embryonic dorsal–ventral patterning in Drosophila, two members of the bone morphogenetic protein (BMP) family, Decapentaplegic (Dpp) and Screw (Scw), are broadly transcribed but promote receptor-mediated signalling in a restricted subset of expressing cells2,3,4. Here we use a novel immunostaining protocol to visualize receptor-bound BMPs and show that both proteins become localized to a sharp stripe of dorsal cells. We demonstrate that proper BMP localization involves two distinct processes. First, Dpp undergoes directed, long-range extracellular transport. Scw also undergoes long-range movement, but can do so independently of Dpp transport. Second, an intracellular positive feedback circuit promotes future ligand binding as a function of previous signalling strength. These data elicit a model in which extracellular Dpp transport initially creates a shallow gradient of BMP binding that is acted on by positive intracellular feedback to produce two stable states of BMP–receptor interactions, a spatial bistability in which BMP binding and signalling capabilities are high in dorsal-most cells and low in lateral cells.

Suggested Citation

  • Yu-Chiun Wang & Edwin L. Ferguson, 2005. "Spatial bistability of Dpp–receptor interactions during Drosophila dorsal–ventral patterning," Nature, Nature, vol. 434(7030), pages 229-234, March.
  • Handle: RePEc:nat:nature:v:434:y:2005:i:7030:d:10.1038_nature03318
    DOI: 10.1038/nature03318
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    Cited by:

    1. Dimitri Breda & Davide Frizzera & Giulia Giordano & Elisa Seffin & Virginia Zanni & Desiderato Annoscia & Christopher J. Topping & Franco Blanchini & Francesco Nazzi, 2022. "A deeper understanding of system interactions can explain contradictory field results on pesticide impact on honey bees," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Tomas Malinauskas & Gareth Moore & Amalie F. Rudolf & Holly Eggington & Hayley L. Belnoue-Davis & Kamel El Omari & Samuel C. Griffiths & Rachel E. Woolley & Ramona Duman & Armin Wagner & Simon J. Leed, 2024. "Molecular mechanism of BMP signal control by Twisted gastrulation," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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