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An autoregulatory circuit for long-range self-organization in Dictyostelium cell populations

Author

Listed:
  • Satoshi Sawai

    (Princeton University)

  • Peter A. Thomason

    (Princeton University)

  • Edward C. Cox

    (Princeton University)

Abstract

cAMP followers The slime mould Dictyostelium discoideum is popular with cell biologists as a model for a multicellular way of life. When food is short its free-living soil amoebae aggregate to form a multicellular body that differentiates and produces spores. Work by Gerisch and others in the 1970s showed that aggregation is controlled by pulses of cyclic AMP, and now experiments with mutants lacking cAMP-dependent protein kinase A show how this system works. Cells communicate via a cAMP signal relay to create outwardly propagating waves of cAMP that control inward movement of cells. Numerical models suggests that self-organization is fine-tuned by a genetic circuit acting via protein kinase A to create an overall wave pattern; in its absence a series of unconnected spiral cores develops. Other systems, such as heart muscle, may act similarly to suppress deleterious spiral waves.

Suggested Citation

  • Satoshi Sawai & Peter A. Thomason & Edward C. Cox, 2005. "An autoregulatory circuit for long-range self-organization in Dictyostelium cell populations," Nature, Nature, vol. 433(7023), pages 323-326, January.
    • Handle: RePEc:nat:nature:v:433:y:2005:i:7023:d:10.1038_nature03228
    DOI: 10.1038/nature03228
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    Cited by:

    1. Can Guven & Erin Rericha & Edward Ott & Wolfgang Losert, 2013. "Modeling and Measuring Signal Relay in Noisy Directed Migration of Cell Groups," PLOS Computational Biology, Public Library of Science, vol. 9(5), pages 1-13, May.
    2. Fernando W Rossine & Ricardo Martinez-Garcia & Allyson E Sgro & Thomas Gregor & Corina E Tarnita, 2020. "Eco-evolutionary significance of “loners”," PLOS Biology, Public Library of Science, vol. 18(3), pages 1-27, March.

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