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Nucleolar proteome dynamics

Author

Listed:
  • Jens S. Andersen

    (Department of Biochemistry and Molecular Biology)

  • Yun W. Lam

    (Wellcome Trust Biocentre, MSI/WTB Complex, University of Dundee)

  • Anthony K. L. Leung

    (Wellcome Trust Biocentre, MSI/WTB Complex, University of Dundee
    Massachusetts Institute of Technology)

  • Shao-En Ong

    (Department of Biochemistry and Molecular Biology)

  • Carol E. Lyon

    (Wellcome Trust Biocentre, MSI/WTB Complex, University of Dundee)

  • Angus I. Lamond

    (Wellcome Trust Biocentre, MSI/WTB Complex, University of Dundee)

  • Matthias Mann

    (Department of Biochemistry and Molecular Biology)

Abstract

Recipe for a nucleolus The nucleolus is the cellular organelle that manufactures ribosomes and plays a part in many vital process including cell-cycle regulation and senescence. Using the latest proteomics technologies, Andersen et al. have generated a comprehensive list of nucleolar proteins. Over 690 proteins were found in the in the nucleolar preparation, including Werner's syndrome helicase and various regulatory proteins. The technology also allows analysis of changes in relative levels of proteins as a result of perturbing growth conditions with drugs. This paints a picture of a dynamic proteome: in effect there may be no definitive proteome for the nucleolus or any other organelle, rather there is a series of overlapping proteomes corresponding to different cell states.

Suggested Citation

  • Jens S. Andersen & Yun W. Lam & Anthony K. L. Leung & Shao-En Ong & Carol E. Lyon & Angus I. Lamond & Matthias Mann, 2005. "Nucleolar proteome dynamics," Nature, Nature, vol. 433(7021), pages 77-83, January.
    • Handle: RePEc:nat:nature:v:433:y:2005:i:7021:d:10.1038_nature03207
    DOI: 10.1038/nature03207
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    Cited by:

    1. Cristiana Bersaglieri & Jelena Kresoja-Rakic & Shivani Gupta & Dominik Bär & Rostyslav Kuzyakiv & Martina Panatta & Raffaella Santoro, 2022. "Genome-wide maps of nucleolus interactions reveal distinct layers of repressive chromatin domains," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. Jan Andreas Ruland & Annika Marie Krüger & Kerstin Dörner & Rohan Bhatia & Sabine Wirths & Daniel Poetes & Ulrike Kutay & Jan Peter Siebrasse & Ulrich Kubitscheck, 2021. "Nuclear export of the pre-60S ribosomal subunit through single nuclear pores observed in real time," Nature Communications, Nature, vol. 12(1), pages 1-12, December.

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