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Functional regeneration after laser axotomy

Author

Listed:
  • Mehmet Fatih Yanik

    (Ginzton Laboratory, Stanford University)

  • Hulusi Cinar

    (Sinsheimer Laboratories, University of California)

  • Hediye Nese Cinar

    (Sinsheimer Laboratories, University of California)

  • Andrew D. Chisholm

    (Sinsheimer Laboratories, University of California)

  • Yishi Jin

    (Sinsheimer Laboratories, University of California
    Howard Hughes Medical Institute, University of California)

  • Adela Ben-Yakar

    (Ginzton Laboratory, Stanford University
    University of Texas at Austin)

Abstract

Understanding how nerves regenerate is an important step towards developing treatments for human neurological disease1, but investigation has so far been limited to complex organisms (mouse and zebrafish2) in the absence of precision techniques for severing axons (axotomy). Here we use femtosecond laser surgery for axotomy in the roundworm Caenorhabditis elegans and show that these axons functionally regenerate after the operation. Application of this precise surgical technique should enable nerve regeneration to be studied in vivo in its most evolutionarily simple form.

Suggested Citation

  • Mehmet Fatih Yanik & Hulusi Cinar & Hediye Nese Cinar & Andrew D. Chisholm & Yishi Jin & Adela Ben-Yakar, 2004. "Functional regeneration after laser axotomy," Nature, Nature, vol. 432(7019), pages 822-822, December.
    • Handle: RePEc:nat:nature:v:432:y:2004:i:7019:d:10.1038_432822a
    DOI: 10.1038/432822a
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    1. Maxim R. Shcherbakov & Giovanni Sartorello & Simin Zhang & Joshua Bocanegra & Melissa Bosch & Michael Tripepi & Noah Talisa & Abdallah AlShafey & Joseph Smith & Stephen Londo & François Légaré & Enam , 2023. "Nanoscale reshaping of resonant dielectric microstructures by light-driven explosions," Nature Communications, Nature, vol. 14(1), pages 1-9, December.

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