Author
Listed:
- Ping Xu
(Virginia Commonwealth University
Virginia Commonwealth University
Virginia Commonwealth University)
- Giovanni Widmer
(Tufts University School of Veterinary Medicine)
- Yingping Wang
(Virginia Commonwealth University
Virginia Commonwealth University)
- Luiz S. Ozaki
(Virginia Commonwealth University
Virginia Commonwealth University)
- Joao M. Alves
(Virginia Commonwealth University
Virginia Commonwealth University)
- Myrna G. Serrano
(Virginia Commonwealth University
Virginia Commonwealth University)
- Daniela Puiu
(Virginia Commonwealth University)
- Patricio Manque
(Virginia Commonwealth University
Virginia Commonwealth University)
- Donna Akiyoshi
(Tufts University School of Veterinary Medicine)
- Aaron J. Mackey
(University of Virginia
University of Pennsylvania)
- William R. Pearson
(University of Virginia)
- Paul H. Dear
(MRC Laboratory of Molecular Biology)
- Alan T. Bankier
(MRC Laboratory of Molecular Biology)
- Darrell L. Peterson
(Virginia Commonwealth University)
- Mitchell S. Abrahamsen
(University of Minnesota
University of Minnesota)
- Vivek Kapur
(University of Minnesota
University of Minnesota)
- Saul Tzipori
(Tufts University School of Veterinary Medicine)
- Gregory A. Buck
(Virginia Commonwealth University
Virginia Commonwealth University)
Abstract
Cryptosporidium species cause acute gastroenteritis and diarrhoea worldwide. They are members of the Apicomplexa—protozoan pathogens that invade host cells by using a specialized apical complex and are usually transmitted by an invertebrate vector or intermediate host. In contrast to other Apicomplexans, Cryptosporidium is transmitted by ingestion of oocysts and completes its life cycle in a single host. No therapy is available, and control focuses on eliminating oocysts in water supplies1. Two species, C. hominis and C. parvum, which differ in host range, genotype and pathogenicity, are most relevant to humans1,2,3. C. hominis is restricted to humans, whereas C. parvum also infects other mammals2. Here we describe the eight-chromosome ∼9.2-million-base genome of C. hominis2. The complement of C. hominis protein-coding genes shows a striking concordance with the requirements imposed by the environmental niches the parasite inhabits. Energy metabolism is largely from glycolysis. Both aerobic and anaerobic metabolisms are available, the former requiring an alternative electron transport system in a simplified mitochondrion. Biosynthesis capabilities are limited, explaining an extensive array of transporters. Evidence of an apicoplast is absent, but genes associated with apical complex organelles are present. C. hominis and C. parvum exhibit very similar gene complements, and phenotypic differences between these parasites must be due to subtle sequence divergence.
Suggested Citation
Ping Xu & Giovanni Widmer & Yingping Wang & Luiz S. Ozaki & Joao M. Alves & Myrna G. Serrano & Daniela Puiu & Patricio Manque & Donna Akiyoshi & Aaron J. Mackey & William R. Pearson & Paul H. Dear & A, 2004.
"The genome of Cryptosporidium hominis,"
Nature, Nature, vol. 431(7012), pages 1107-1112, October.
Handle:
RePEc:nat:nature:v:431:y:2004:i:7012:d:10.1038_nature02977
DOI: 10.1038/nature02977
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Citations
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Cited by:
- Rui Xu & Wandy L. Beatty & Valentin Greigert & William H. Witola & L. David Sibley, 2024.
"Multiple pathways for glucose phosphate transport and utilization support growth of Cryptosporidium parvum,"
Nature Communications, Nature, vol. 15(1), pages 1-15, December.
- José A Fernández Robledo & Gerardo R Vasta & Nicholas R Record, 2014.
"Protozoan Parasites of Bivalve Molluscs: Literature Follows Culture,"
PLOS ONE, Public Library of Science, vol. 9(6), pages 1-9, June.
- Corey C. Holt & Elisabeth Hehenberger & Denis V. Tikhonenkov & Victoria K. L. Jacko-Reynolds & Noriko Okamoto & Elizabeth C. Cooney & Nicholas A. T. Irwin & Patrick J. Keeling, 2023.
"Multiple parallel origins of parasitic Marine Alveolates,"
Nature Communications, Nature, vol. 14(1), pages 1-14, December.
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