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Role for a cortical input to hippocampal area CA1 in the consolidation of a long-term memory

Author

Listed:
  • Miguel Remondes

    (Caltech/HHMI)

  • Erin M. Schuman

    (Caltech/HHMI)

Abstract

A dialogue between the hippocampus and the neocortex is thought to underlie the formation, consolidation and retrieval of episodic memories1,2,3,4, although the nature of this cortico-hippocampal communication is poorly understood. Using selective electrolytic lesions in rats, here we examined the role of the direct entorhinal projection (temporoammonic, TA) to the hippocampal area CA1 in short-term (24 hours) and long-term (four weeks) spatial memory in the Morris water maze. When short-term memory was examined, both sham- and TA-lesioned animals showed a significant preference for the target quadrant. When re-tested four weeks later, sham-lesioned animals exhibited long-term memory; in contrast, the TA-lesioned animals no longer showed target quadrant preference. Many long-lasting memories require a process called consolidation, which involves the exchange of information between the cortex and hippocampus3,5,6. The disruption of long-term memory by the TA lesion could reflect a requirement for TA input during either the acquisition or consolidation of long-term memory. To distinguish between these possibilities, we trained animals, verified their spatial memory 24 hours later, and then subjected trained animals to TA lesions. TA-lesioned animals still exhibited a deficit in long-term memory, indicating a disruption of consolidation. Animals in which the TA lesion was delayed by three weeks, however, showed a significant preference for the target quadrant, indicating that the memory had already been adequately consolidated at the time of the delayed lesion. These results indicate that, after learning, ongoing cortical input conveyed by the TA path is required to consolidate long-term spatial memory.

Suggested Citation

  • Miguel Remondes & Erin M. Schuman, 2004. "Role for a cortical input to hippocampal area CA1 in the consolidation of a long-term memory," Nature, Nature, vol. 431(7009), pages 699-703, October.
  • Handle: RePEc:nat:nature:v:431:y:2004:i:7009:d:10.1038_nature02965
    DOI: 10.1038/nature02965
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    Cited by:

    1. Isabella C. Wagner & Luise P. Graichen & Boryana Todorova & Andre Lüttig & David B. Omer & Matthias Stangl & Claus Lamm, 2023. "Entorhinal grid-like codes and time-locked network dynamics track others navigating through space," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Yann Vanrobaeys & Utsav Mukherjee & Lucy Langmack & Stacy E. Beyer & Ethan Bahl & Li-Chun Lin & Jacob J. Michaelson & Ted Abel & Snehajyoti Chatterjee, 2023. "Mapping the spatial transcriptomic signature of the hippocampus during memory consolidation," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Yann Vanrobaeys & Zeru J. Peterson & Emily. N. Walsh & Snehajyoti Chatterjee & Li-Chun Lin & Lisa C. Lyons & Thomas Nickl-Jockschat & Ted Abel, 2023. "Spatial transcriptomics reveals unique gene expression changes in different brain regions after sleep deprivation," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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