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Recollection-like memory retrieval in rats is dependent on the hippocampus

Author

Listed:
  • Norbert J. Fortin

    (Boston University)

  • Sean P. Wright

    (Boston University)

  • Howard Eichenbaum

    (Boston University)

Abstract

Recognition memory may be supported by two independent types of retrieval, conscious recollection of a specific experience and a sense of familiarity gained from previous exposure to particular stimuli1,2. In humans, signal detection techniques have been used to distinguish recollection and familiarity, respectively, in asymmetrical and curvilinear components of their receiver operating characteristic (ROC) curves, standard curves that represent item recognition across different levels of confidence or bias. To determine whether animals also employ multiple processes in recognition memory and to explore the anatomical basis of this distinction, we adapted these techniques to examine odour recognition memory in rats. Their ROC curve had asymmetrical and curvilinear components, indicating the existence of both recollection and familiarity in rats. Furthermore, following selective damage to the hippocampus the ROC curve became entirely symmetrical and remained curvilinear, supporting the view that the hippocampus specifically mediates the capacity for recollection.

Suggested Citation

  • Norbert J. Fortin & Sean P. Wright & Howard Eichenbaum, 2004. "Recollection-like memory retrieval in rats is dependent on the hippocampus," Nature, Nature, vol. 431(7005), pages 188-191, September.
    • Handle: RePEc:nat:nature:v:431:y:2004:i:7005:d:10.1038_nature02853
    DOI: 10.1038/nature02853
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    Cited by:

    1. Mariam Aly & Andrew P Yonelinas, 2012. "Bridging Consciousness and Cognition in Memory and Perception: Evidence for Both State and Strength Processes," PLOS ONE, Public Library of Science, vol. 7(1), pages 1-16, January.
    2. Benjamin M. Basile & Vincent D. Costa & Jamie L. Schafroth & Chloe L. Karaskiewicz & Daniel R. Lucas & Elisabeth A. Murray, 2023. "The amygdala is not necessary for the familiarity aspect of recognition memory," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    3. Duarte S Viana & Isabel Gordo & Élio Sucena & Marta A P Moita, 2010. "Cognitive and Motivational Requirements for the Emergence of Cooperation in a Rat Social Game," PLOS ONE, Public Library of Science, vol. 5(1), pages 1-9, January.

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