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Summing up the noise in gene networks

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  • Johan Paulsson

    (Princeton University
    Centre for Mathematical Sciences, University of Cambridge)

Abstract

Random fluctuations in genetic networks are inevitable as chemical reactions are probabilistic and many genes, RNAs and proteins are present in low numbers per cell. Such ‘noise’ affects all life processes and has recently been measured using green fluorescent protein (GFP). Two studies show that negative feedback suppresses noise, and three others identify the sources of noise in gene expression. Here I critically analyse these studies and present a simple equation that unifies and extends both the mathematical and biological perspectives.

Suggested Citation

  • Johan Paulsson, 2004. "Summing up the noise in gene networks," Nature, Nature, vol. 427(6973), pages 415-418, January.
    • Handle: RePEc:nat:nature:v:427:y:2004:i:6973:d:10.1038_nature02257
    DOI: 10.1038/nature02257
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