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Influence of TOR kinase on lifespan in C. elegans

Author

Listed:
  • Tibor Vellai

    (University of Fribourg)

  • Krisztina Takacs-Vellai

    (University of Fribourg)

  • Yue Zhang

    (University of Fribourg)

  • Attila L. Kovacs

    (Eötvös Loránd University)

  • László Orosz

    (Eötvös Loránd University
    Agricultural Biotechnology Centre)

  • Fritz Müller

    (University of Fribourg)

Abstract

The group of enzymes known as TOR (for 'target of rapamycin') kinases regulates cell growth and proliferation in response to nutrients and hormone-dependent mitogenic signals1,2. Here we show that TOR deficiency in the nematode Caenorhabditis elegans more than doubles its natural lifespan. This new function for TOR signalling in ageing control may represent a link between nutrition, metabolism and longevity.

Suggested Citation

  • Tibor Vellai & Krisztina Takacs-Vellai & Yue Zhang & Attila L. Kovacs & László Orosz & Fritz Müller, 2003. "Influence of TOR kinase on lifespan in C. elegans," Nature, Nature, vol. 426(6967), pages 620-620, December.
    • Handle: RePEc:nat:nature:v:426:y:2003:i:6967:d:10.1038_426620a
    DOI: 10.1038/426620a
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    Cited by:

    1. Smita Majumder & Arlan Richardson & Randy Strong & Salvatore Oddo, 2011. "Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits," PLOS ONE, Public Library of Science, vol. 6(9), pages 1-11, September.
    2. Paola Fabrizio & Shawn Hoon & Mehrnaz Shamalnasab & Abdulaye Galbani & Min Wei & Guri Giaever & Corey Nislow & Valter D Longo, 2010. "Genome-Wide Screen in Saccharomyces cerevisiae Identifies Vacuolar Protein Sorting, Autophagy, Biosynthetic, and tRNA Methylation Genes Involved in Life Span Regulation," PLOS Genetics, Public Library of Science, vol. 6(7), pages 1-14, July.

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