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BSE in sheep bred for resistance to infection

Author

Listed:
  • Fiona Houston

    (Institute for Animal Health, Compton)

  • Wilfred Goldmann

    (IAH Neuropathogenesis Unit)

  • Angela Chong

    (IAH Neuropathogenesis Unit)

  • Martin Jeffrey

    (Veterinary Laboratories Agency Lasswade, Pentlands Science Park)

  • Lorenzo González

    (Veterinary Laboratories Agency Lasswade, Pentlands Science Park)

  • James Foster

    (IAH Neuropathogenesis Unit)

  • David Parnham

    (IAH Neuropathogenesis Unit)

  • Nora Hunter

    (IAH Neuropathogenesis Unit)

Abstract

Selective breeding for disease-resistant genotypes is being pursued as a means of eradicating scrapie (and bovine spongiform encephalopathy (BSE), if it is present) from sheep flocks. Here we show that the genotype associated with the highest resistance can still be infected with BSE by intracerebral inoculation. Although the relevance of this finding to sheep exposed to natural infection remains to be determined, it may have important implications for disease-eradication strategies.

Suggested Citation

  • Fiona Houston & Wilfred Goldmann & Angela Chong & Martin Jeffrey & Lorenzo González & James Foster & David Parnham & Nora Hunter, 2003. "BSE in sheep bred for resistance to infection," Nature, Nature, vol. 423(6939), pages 498-498, May.
    • Handle: RePEc:nat:nature:v:423:y:2003:i:6939:d:10.1038_423498a
    DOI: 10.1038/423498a
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    Cited by:

    1. Babatunde O. Alao & Andrew B. Falowo & Amanda Chulayo & Voster Muchenje, 2017. "The Potential of Animal By-Products in Food Systems: Production, Prospects and Challenges," Sustainability, MDPI, vol. 9(7), pages 1-18, June.
    2. Eric P. M. Grist, 2005. "Transmissible Spongiform Encephalopathy Risk Assessment: The UK experience," Risk Analysis, John Wiley & Sons, vol. 25(3), pages 519-532, June.

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