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Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1

Author

Listed:
  • Emmanuel Treiner

    (Laboratoire d'Immunologie and INSERM U520, Institut Curie)

  • Livine Duban

    (Laboratoire d'Immunologie and INSERM U520, Institut Curie)

  • Seiamak Bahram

    (INSERM–CReS, Centre de Recherche d'Immunologie et d'Hématologie)

  • Mirjana Radosavljevic

    (INSERM–CReS, Centre de Recherche d'Immunologie et d'Hématologie)

  • Valerie Wanner

    (INSERM–CReS, Centre de Recherche d'Immunologie et d'Hématologie)

  • Florence Tilloy

    (Laboratoire d'Immunologie and INSERM U520, Institut Curie)

  • Pierre Affaticati

    (Laboratoire d'Immunologie and INSERM U520, Institut Curie)

  • Susan Gilfillan

    (Washington University School of Medicine)

  • Olivier Lantz

    (Laboratoire d'Immunologie and INSERM U520, Institut Curie)

Abstract

The evolutionary conservation of T lymphocyte subsets bearing T-cell receptors (TCRs) using invariant α-chains is indicative of unique functions. CD1d-restricted natural killer T (NK-T) cells that express an invariant Vα14 TCRα chain have been implicated in microbial and tumour responses, as well as in auto-immunity1,2. Here we show that T cells that express the canonical hVα7.2-Jα33 or mVα19-Jα33 TCR rearrangement3 are preferentially located in the gut lamina propria of humans and mice, respectively, and are therefore genuine mucosal-associated invariant T (MAIT) cells. Selection and/or expansion of this population requires B lymphocytes, as MAIT cells are absent in B-cell-deficient patients and mice. In addition, we show that MAIT cells are selected and/or restricted by MR1, a monomorphic major histocompatibility complex class I-related molecule that is markedly conserved in diverse mammalian species4. MAIT cells are not present in germ-free mice, indicating that commensal flora is required for their expansion in the gut lamina propria. This indicates that MAIT cells are probably involved in the host response at the site of pathogen entry, and may regulate intestinal B-cell activity.

Suggested Citation

  • Emmanuel Treiner & Livine Duban & Seiamak Bahram & Mirjana Radosavljevic & Valerie Wanner & Florence Tilloy & Pierre Affaticati & Susan Gilfillan & Olivier Lantz, 2003. "Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1," Nature, Nature, vol. 422(6928), pages 164-169, March.
    • Handle: RePEc:nat:nature:v:422:y:2003:i:6928:d:10.1038_nature01433
    DOI: 10.1038/nature01433
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    Citations

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    Cited by:

    1. Mark Walkenhorst & Jana K. Sonner & Nina Meurs & Jan Broder Engler & Simone Bauer & Ingo Winschel & Marcel S. Woo & Lukas Raich & Iris Winkler & Vanessa Vieira & Lisa Unger & Gabriela Salinas & Olivie, 2024. "Protective effect of TCR-mediated MAIT cell activation during experimental autoimmune encephalomyelitis," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Robert Z Harms & Kristina M Lorenzo & Kevin P Corley & Monina S Cabrera & Nora E Sarvetnick, 2015. "Altered CD161bright CD8+ Mucosal Associated Invariant T (MAIT)-Like Cell Dynamics and Increased Differentiation States among Juvenile Type 1 Diabetics," PLOS ONE, Public Library of Science, vol. 10(1), pages 1-21, January.
    3. Ann-Christin Gnirck & Marie-Sophie Philipp & Alex Waterhölter & Malte Wunderlich & Nikhat Shaikh & Virginia Adamiak & Lena Henneken & Tobias Kautz & Tingting Xiong & Daniela Klaus & Pascal Tomczyk & M, 2023. "Mucosal-associated invariant T cells contribute to suppression of inflammatory myeloid cells in immune-mediated kidney disease," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    4. Lauren Stern & Helen M. McGuire & Selmir Avdic & Barbara Fazekas de St Groth & David Gottlieb & Allison Abendroth & Emily Blyth & Barry Slobedman, 2022. "Immunoprofiling reveals cell subsets associated with the trajectory of cytomegalovirus reactivation post stem cell transplantation," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    5. Kensuke Shibata & Chihiro Motozono & Masamichi Nagae & Takashi Shimizu & Eri Ishikawa & Daisuke Motooka & Daisuke Okuzaki & Yoshihiro Izumi & Masatomo Takahashi & Nao Fujimori & James B. Wing & Takahi, 2022. "Symbiotic bacteria-dependent expansion of MR1-reactive T cells causes autoimmunity in the absence of Bcl11b," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    6. Morgane Mabire & Pushpa Hegde & Adel Hammoutene & Jinghong Wan & Charles Caër & Rola Al Sayegh & Mathilde Cadoux & Manon Allaire & Emmanuel Weiss & Tristan Thibault-Sogorb & Olivier Lantz & Michèle Go, 2023. "MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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