MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming
Author
Abstract
Suggested Citation
DOI: 10.1038/s41467-023-37453-5
Download full text from publisher
References listed on IDEAS
- P. Ramachandran & R. Dobie & J. R. Wilson-Kanamori & E. F. Dora & B. E. P. Henderson & N. T. Luu & J. R. Portman & K. P. Matchett & M. Brice & J. A. Marwick & R. S. Taylor & M. Efremova & R. Vento-Tor, 2019. "Resolving the fibrotic niche of human liver cirrhosis at single-cell level," Nature, Nature, vol. 575(7783), pages 512-518, November.
- Petter Holland & Helene Knævelsrud & Kristiane Søreng & Benan J. Mathai & Alf Håkon Lystad & Serhiy Pankiv & Gunnveig T. Bjørndal & Sebastian W. Schultz & Viola H. Lobert & Robin B. Chan & Bowen Zhou , 2016. "HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels," Nature Communications, Nature, vol. 7(1), pages 1-13, December.
- Lars Kjer-Nielsen & Onisha Patel & Alexandra J. Corbett & Jérôme Le Nours & Bronwyn Meehan & Ligong Liu & Mugdha Bhati & Zhenjun Chen & Lyudmila Kostenko & Rangsima Reantragoon & Nicholas A. Williamso, 2012. "MR1 presents microbial vitamin B metabolites to MAIT cells," Nature, Nature, vol. 491(7426), pages 717-723, November.
- Emmanuel Treiner & Livine Duban & Seiamak Bahram & Mirjana Radosavljevic & Valerie Wanner & Florence Tilloy & Pierre Affaticati & Susan Gilfillan & Olivier Lantz, 2003. "addendum: Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1," Nature, Nature, vol. 423(6943), pages 1018-1018, June.
- Emmanuel Treiner & Livine Duban & Seiamak Bahram & Mirjana Radosavljevic & Valerie Wanner & Florence Tilloy & Pierre Affaticati & Susan Gilfillan & Olivier Lantz, 2003. "Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1," Nature, Nature, vol. 422(6928), pages 164-169, March.
- Pushpa Hegde & Emmanuel Weiss & Valérie Paradis & Jinghong Wan & Morgane Mabire & Sukriti Sukriti & Pierre-Emmanuel Rautou & Miguel Albuquerque & Olivia Picq & Abhishak Chandra Gupta & Gladys Ferrere , 2018. "Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
- Nadjet Gacem & Anthula Kavo & Lisa Zerad & Laurence Richard & Stephane Mathis & Raj P. Kapur & Melanie Parisot & Jeanne Amiel & Sylvie Dufour & Pierre de la Grange & Veronique Pingault & Jean Michel V, 2020. "ADAR1 mediated regulation of neural crest derived melanocytes and Schwann cell development," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
Most related items
These are the items that most often cite the same works as this one and are cited by the same works as this one.- Lauren Stern & Helen M. McGuire & Selmir Avdic & Barbara Fazekas de St Groth & David Gottlieb & Allison Abendroth & Emily Blyth & Barry Slobedman, 2022. "Immunoprofiling reveals cell subsets associated with the trajectory of cytomegalovirus reactivation post stem cell transplantation," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
- Ann-Christin Gnirck & Marie-Sophie Philipp & Alex Waterhölter & Malte Wunderlich & Nikhat Shaikh & Virginia Adamiak & Lena Henneken & Tobias Kautz & Tingting Xiong & Daniela Klaus & Pascal Tomczyk & M, 2023. "Mucosal-associated invariant T cells contribute to suppression of inflammatory myeloid cells in immune-mediated kidney disease," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
- Mark Walkenhorst & Jana K. Sonner & Nina Meurs & Jan Broder Engler & Simone Bauer & Ingo Winschel & Marcel S. Woo & Lukas Raich & Iris Winkler & Vanessa Vieira & Lisa Unger & Gabriela Salinas & Olivie, 2024. "Protective effect of TCR-mediated MAIT cell activation during experimental autoimmune encephalomyelitis," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
- Robert Z Harms & Kristina M Lorenzo & Kevin P Corley & Monina S Cabrera & Nora E Sarvetnick, 2015. "Altered CD161bright CD8+ Mucosal Associated Invariant T (MAIT)-Like Cell Dynamics and Increased Differentiation States among Juvenile Type 1 Diabetics," PLOS ONE, Public Library of Science, vol. 10(1), pages 1-21, January.
- Kensuke Shibata & Chihiro Motozono & Masamichi Nagae & Takashi Shimizu & Eri Ishikawa & Daisuke Motooka & Daisuke Okuzaki & Yoshihiro Izumi & Masatomo Takahashi & Nao Fujimori & James B. Wing & Takahi, 2022. "Symbiotic bacteria-dependent expansion of MR1-reactive T cells causes autoimmunity in the absence of Bcl11b," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
- Agnieska Brazovskaja & Tomás Gomes & Rene Holtackers & Philipp Wahle & Christiane Körner & Zhisong He & Theresa Schaffer & Julian Connor Eckel & René Hänsel & Malgorzata Santel & Makiko Seimiya & Timm, 2024. "Cell atlas of the regenerating human liver after portal vein embolization," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
- Huachun Cui & Sami Banerjee & Na Xie & Musaddique Hussain & Ashish Jaiswal & Hongli Liu & Tejaswini Kulkarni & Veena B. Antony & Rui-Ming Liu & Marco Colonna & Gang Liu, 2025. "TREM2 promotes lung fibrosis via controlling alveolar macrophage survival and pro-fibrotic activity," Nature Communications, Nature, vol. 16(1), pages 1-15, December.
- Adriana A. de Jesus & Guibin Chen & Dan Yang & Tomas Brdicka & Natasha M. Ruth & David Bennin & Dita Cebecauerova & Hana Malcova & Helen Freeman & Neil Martin & Karel Svojgr & Murray H. Passo & Farzan, 2023. "Constitutively active Lyn kinase causes a cutaneous small vessel vasculitis and liver fibrosis syndrome," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
- Han-Ying Huang & Yan-Zhou Chen & Chuang Zhao & Xin-Nan Zheng & Kai Yu & Jia-Xing Yue & Huai-Qiang Ju & Yan-Xia Shi & Lin Tian, 2024. "Alternations in inflammatory macrophage niche drive phenotypic and functional plasticity of Kupffer cells," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
- Paula P. Coelho & Geoffrey G. Hesketh & Annika Pedersen & Elena Kuzmin & Anne-Marie N. Fortier & Emily S. Bell & Colin D. H. Ratcliffe & Anne-Claude Gingras & Morag Park, 2022. "Endosomal LC3C-pathway selectively targets plasma membrane cargo for autophagic degradation," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
- Caitriona M. McEvoy & Julia M. Murphy & Lin Zhang & Sergi Clotet-Freixas & Jessica A. Mathews & James An & Mehran Karimzadeh & Delaram Pouyabahar & Shenghui Su & Olga Zaslaver & Hannes Röst & Rangi Ar, 2022. "Single-cell profiling of healthy human kidney reveals features of sex-based transcriptional programs and tissue-specific immunity," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
- Mayra Cruz Tleugabulova & Sandra P. Melo & Aaron Wong & Alexander Arlantico & Meizi Liu & Joshua D. Webster & Julia Lau & Antonie Lechner & Basak Corak & Jonathan J. Hodgins & Venkata S. Garlapati & M, 2024. "Induction of a distinct macrophage population and protection from lung injury and fibrosis by Notch2 blockade," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
- Brianna R. Watson & Biplab Paul & Raza Ur Rahman & Liat Amir-Zilberstein & Åsa Segerstolpe & Eliana T. Epstein & Shane Murphy & Ludwig Geistlinger & Tyrone Lee & Angela Shih & Jacques Deguine & Ramnik, 2025. "Spatial transcriptomics of healthy and fibrotic human liver at single-cell resolution," Nature Communications, Nature, vol. 16(1), pages 1-16, December.
- Hui Xia & Catherine R. Dufour & Younes Medkour & Charlotte Scholtes & Yonghong Chen & Christina Guluzian & Wafa B’chir & Vincent Giguère, 2023. "Hepatocyte FBXW7-dependent activity of nutrient-sensing nuclear receptors controls systemic energy homeostasis and NASH progression in male mice," Nature Communications, Nature, vol. 14(1), pages 1-24, December.
- Keisuke Tabata & Vibhu Prasad & David Paul & Ji-Young Lee & Minh-Tu Pham & Woan-Ing Twu & Christopher J. Neufeldt & Mirko Cortese & Berati Cerikan & Yannick Stahl & Sebastian Joecks & Cong Si Tran & C, 2021. "Convergent use of phosphatidic acid for hepatitis C virus and SARS-CoV-2 replication organelle formation," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
- Carlos Fernández Moro & Natalie Geyer & Sara Harrizi & Yousra Hamidi & Sara Söderqvist & Danyil Kuznyecov & Evelina Tidholm Qvist & Media Salmonson Schaad & Laura Hermann & Amanda Lindberg & Rainer L., 2023. "An idiosyncratic zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
- Li-Xian Yang & Chuangye Qi & Si Lu & Xiang-Shi Ye & Parnaz Merikhian & Du-Yu Zhang & Tao Yao & Jiang-Sha Zhao & Ying Wu & Yongshi Jia & Bo Shan & Jinghai Chen & Xiaozhou Mou & Jia You & Wenbo Li & Yu-, 2025. "Alleviation of liver fibrosis by inhibiting a non-canonical ATF4-regulated enhancer program in hepatic stellate cells," Nature Communications, Nature, vol. 16(1), pages 1-15, December.
- Michael J. Munson & Benan J. Mathai & Matthew Yoke Wui Ng & Laura Trachsel-Moncho & Laura R. Ballina & Sebastian W. Schultz & Yahyah Aman & Alf H. Lystad & Sakshi Singh & Sachin Singh & Jørgen Wesche , 2021. "GAK and PRKCD are positive regulators of PRKN-independent mitophagy," Nature Communications, Nature, vol. 12(1), pages 1-22, December.
- Shanshan He & Xiaoyang Li & Yuanyuan He & Ling Guo & Yunzhou Dong & Leilei Wang & Lan Yang & Lin Li & Shiyun Huang & Jiali Fu & Qing Lin & Zhirong Zhang & Ling Zhang, 2025. "High-density lipoprotein nanoparticles spontaneously target to damaged renal tubules and alleviate renal fibrosis by remodeling the fibrotic niches," Nature Communications, Nature, vol. 16(1), pages 1-20, December.
- Michael T. H. Ng & Rowie Borst & Hamez Gacaferi & Sarah Davidson & Jessica E. Ackerman & Peter A. Johnson & Caio C. Machado & Ian Reekie & Moustafa Attar & Dylan Windell & Mariola Kurowska-Stolarska &, 2024. "A single cell atlas of frozen shoulder capsule identifies features associated with inflammatory fibrosis resolution," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
Corrections
All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37453-5. See general information about how to correct material in RePEc.
If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.
If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .
If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .
Please note that corrections may take a couple of weeks to filter through the various RePEc services.