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DNA damage and repair

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  • Errol C. Friedberg

    (Laboratory of Molecular Pathology, University of Texas Southwestern Medical Center)

Abstract

The aesthetic appeal of the DNA double helix initially hindered notions of DNA mutation and repair, which would necessarily interfere with its pristine state. But it has since been recognized that DNA is subject to continuous damage and the cell has an arsenal of ways of responding to such injury. Although mutations or deficiencies in repair can have catastrophic consequences, causing a range of human diseases, mutations are nonetheless fundamental to life and evolution.

Suggested Citation

  • Errol C. Friedberg, 2003. "DNA damage and repair," Nature, Nature, vol. 421(6921), pages 436-440, January.
    • Handle: RePEc:nat:nature:v:421:y:2003:i:6921:d:10.1038_nature01408
    DOI: 10.1038/nature01408
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    Cited by:

    1. Mei-Ling Zhu & Mengyun Wang & Zhi-Gang Cao & Jing He & Ting-Yan Shi & Kai-Qin Xia & Li-Xin Qiu & Qing-Yi Wei, 2012. "Association between the ERCC5 Asp1104His Polymorphism and Cancer Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(7), pages 1-9, July.
    2. Guo, Junfeng & Wang, Fei & Xue, Qianwen & Wang, Mengqing, 2023. "Cluster synchronization control for coupled genetic oscillator networks under denial-of-service attacks: Pinning partial impulsive strategy," Chaos, Solitons & Fractals, Elsevier, vol. 177(C).
    3. Richard A Hubner & Richard D Riley & Lucinda J Billingham & Sanjay Popat, 2011. "Excision Repair Cross-Complementation Group 1 (ERCC1) Status and Lung Cancer Outcomes: A Meta-Analysis of Published Studies and Recommendations," PLOS ONE, Public Library of Science, vol. 6(10), pages 1-10, October.

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