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The immunopathogenesis of sepsis

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  • Jonathan Cohen

    (Brighton & Sussex Medical School)

Abstract

Sepsis is a condition that results from a harmful or damaging host response to infection. Many of the components of the innate immune response that are normally concerned with host defences against infection can, under some circumstances, cause cell and tissue damage and hence multiple organ failure, the clinical hallmark of sepsis. Because of the high mortality of sepsis in the face of standard treatment, many efforts have been made to improve understanding of the dysregulation of the host response in sepsis. As a result, much has been learnt of the basic principles governing bacterial–host interactions, and new opportunities for therapeutic intervention have been revealed.

Suggested Citation

  • Jonathan Cohen, 2002. "The immunopathogenesis of sepsis," Nature, Nature, vol. 420(6917), pages 885-891, December.
    • Handle: RePEc:nat:nature:v:420:y:2002:i:6917:d:10.1038_nature01326
    DOI: 10.1038/nature01326
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    Cited by:

    1. Tristram A. J. Ryan & Alexander Hooftman & Aisling M. Rehill & Matt D. Johansen & Eóin C. O’ Brien & Juliana E. Toller-Kawahisa & Mieszko M. Wilk & Emily A. Day & Hauke J. Weiss & Pourya Sarvari & Emi, 2023. "Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Hao Hong Yiu & Andrea L Graham & Robert F Stengel, 2012. "Dynamics of a Cytokine Storm," PLOS ONE, Public Library of Science, vol. 7(10), pages 1-15, October.

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