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RETRACTED ARTICLE: Pluripotency of mesenchymal stem cells derived from adult marrow

Author

Listed:
  • Yuehua Jiang

    (Stem Cell Institute, University of Minnesota Medical School)

  • Balkrishna N. Jahagirdar

    (Stem Cell Institute, University of Minnesota Medical School
    University of Minnesota Medical School)

  • R. Lee Reinhardt

    (University of Minnesota Medical School)

  • Robert E. Schwartz

    (Stem Cell Institute, University of Minnesota Medical School)

  • C. Dirk Keene

    (University of Minnesota Medical School)

  • Xilma R. Ortiz-Gonzalez

    (University of Minnesota Medical School)

  • Morayma Reyes

    (Stem Cell Institute, University of Minnesota Medical School)

  • Todd Lenvik

    (Stem Cell Institute, University of Minnesota Medical School)

  • Troy Lund

    (Stem Cell Institute, University of Minnesota Medical School)

  • Mark Blackstad

    (Stem Cell Institute, University of Minnesota Medical School)

  • Jingbo Du

    (Stem Cell Institute, University of Minnesota Medical School)

  • Sara Aldrich

    (Stem Cell Institute, University of Minnesota Medical School)

  • Aaron Lisberg

    (Stem Cell Institute, University of Minnesota Medical School)

  • Walter C. Low

    (University of Minnesota Medical School)

  • David A. Largaespada

    (University of Minnesota Medical School)

  • Catherine M. Verfaillie

    (Stem Cell Institute, University of Minnesota Medical School
    University of Minnesota Medical School)

Abstract

We report here that cells co-purifying with mesenchymal stem cells—termed here multipotent adult progenitor cells or MAPCs—differentiate, at the single cell level, not only into mesenchymal cells, but also cells with visceral mesoderm, neuroectoderm and endoderm characteristics in vitro. When injected into an early blastocyst, single MAPCs contribute to most, if not all, somatic cell types. On transplantation into a non-irradiated host, MAPCs engraft and differentiate to the haematopoietic lineage, in addition to the epithelium of liver, lung and gut. Engraftment in the haematopoietic system as well as the gastrointestinal tract is increased when MAPCs are transplanted in a minimally irradiated host. As MAPCs proliferate extensively without obvious senescence or loss of differentiation potential, they may be an ideal cell source for therapy of inherited or degenerative diseases.

Suggested Citation

  • Yuehua Jiang & Balkrishna N. Jahagirdar & R. Lee Reinhardt & Robert E. Schwartz & C. Dirk Keene & Xilma R. Ortiz-Gonzalez & Morayma Reyes & Todd Lenvik & Troy Lund & Mark Blackstad & Jingbo Du & Sara , 2002. "RETRACTED ARTICLE: Pluripotency of mesenchymal stem cells derived from adult marrow," Nature, Nature, vol. 418(6893), pages 41-49, July.
    • Handle: RePEc:nat:nature:v:418:y:2002:i:6893:d:10.1038_nature00870
    DOI: 10.1038/nature00870
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    Cited by:

    1. Géraldine Poncin & Aurore Beaulieu & Chantal Humblet & Albert Thiry & Kimimitsu Oda & Jacques Boniver & Marie-Paule Defresne, 2012. "Characterization of Spontaneous Bone Marrow Recovery after Sublethal Total Body Irradiation: Importance of the Osteoblastic/Adipocytic Balance," PLOS ONE, Public Library of Science, vol. 7(2), pages 1-13, February.
    2. Ling-Li Li & Guohua Ding & Nan Feng & Ming-Huang Wang & Yuh-Shan Ho, 2009. "Global stem cell research trend: Bibliometric analysis as a tool for mapping of trends from 1991 to 2006," Scientometrics, Springer;Akadémiai Kiadó, vol. 80(1), pages 39-58, July.

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