IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v417y2002i6887d10.1038_417452a.html
   My bibliography  Save this article

Transgenic anopheline mosquitoes impaired in transmission of a malaria parasite

Author

Listed:
  • Junitsu Ito

    (Case Western Reserve University, Department of Genetics)

  • Anil Ghosh

    (Case Western Reserve University, Department of Genetics)

  • Luciano A. Moreira

    (Case Western Reserve University, Department of Genetics)

  • Ernst A. Wimmer

    (Universitätsstrasse 30)

  • Marcelo Jacobs-Lorena

    (Case Western Reserve University, Department of Genetics)

Abstract

Malaria is estimated to cause 0.7 to 2.7 million deaths per year, but the actual figures could be substantially higher owing to under-reporting and difficulties in diagnosis1. If no new control measures are developed, the malaria death toll is projected to double in the next 20 years1. Efforts to control the disease are hampered by drug resistance in the Plasmodium parasites, insecticide resistance in mosquitoes, and the lack of an effective vaccine. Because mosquitoes are obligatory vectors for malaria transmission, the spread of malaria could be curtailed by rendering them incapable of transmitting parasites. Many of the tools required for the genetic manipulation of mosquito competence for malaria transmission have been developed. Foreign genes can now be introduced into the germ line of both culicine2,3 and anopheline4 mosquitoes, and these transgenes can be expressed in a tissue-specific manner5,6. Here we report on the use of such tools to generate transgenic mosquitoes that express antiparasitic genes in their midgut epithelium, thus rendering them inefficient vectors for the disease. These findings have significant implications for the development of new strategies for malaria control.

Suggested Citation

  • Junitsu Ito & Anil Ghosh & Luciano A. Moreira & Ernst A. Wimmer & Marcelo Jacobs-Lorena, 2002. "Transgenic anopheline mosquitoes impaired in transmission of a malaria parasite," Nature, Nature, vol. 417(6887), pages 452-455, May.
    • Handle: RePEc:nat:nature:v:417:y:2002:i:6887:d:10.1038_417452a
    DOI: 10.1038/417452a
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/417452a
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/417452a?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Michelle L. Johnson & Bruce A. Hay & Maciej Maselko, 2024. "Altering traits and fates of wild populations with Mendelian DNA sequence modifying Allele Sails," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    2. Vanessa M. Macias & Johanna R. Ohm & Jason L. Rasgon, 2017. "Gene Drive for Mosquito Control: Where Did It Come from and Where Are We Headed?," IJERPH, MDPI, vol. 14(9), pages 1-30, September.
    3. Tales V. Pascini & Yeong Je Jeong & Wei Huang & Zarna R. Pala & Juliana M. Sá & Michael B. Wells & Christopher Kizito & Brendan Sweeney & Thiago L. Alves e Silva & Deborah J. Andrew & Marcelo Jacobs-­, 2022. "Transgenic Anopheles mosquitoes expressing human PAI-1 impair malaria transmission," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:417:y:2002:i:6887:d:10.1038_417452a. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.