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An extensive network of coupling among gene expression machines

Author

Listed:
  • Tom Maniatis

    (Harvard University)

  • Robin Reed

    (Harvard Medical School)

Abstract

Gene expression in eukaryotes requires several multi-component cellular machines. Each machine carries out a separate step in the gene expression pathway, which includes transcription, several pre-messenger RNA processing steps and the export of mature mRNA to the cytoplasm. Recent studies lead to the view that, in contrast to a simple linear assembly line, a complex and extensively coupled network has evolved to coordinate the activities of the gene expression machines. The extensive coupling is consistent with a model in which the machines are tethered to each other to form ‘gene expression factories’ that maximize the efficiency and specificity of each step in gene expression.

Suggested Citation

  • Tom Maniatis & Robin Reed, 2002. "An extensive network of coupling among gene expression machines," Nature, Nature, vol. 416(6880), pages 499-506, April.
    • Handle: RePEc:nat:nature:v:416:y:2002:i:6880:d:10.1038_416499a
    DOI: 10.1038/416499a
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    Cited by:

    1. Lucia Coscujuela Tarrero & Valeria Famà & Giacomo D’Andrea & Simone Maestri & Anna Polo & Stefano Biffo & Mattia Furlan & Mattia Pelizzola, 2024. "Nanodynamo quantifies subcellular RNA dynamics revealing extensive coupling between steps of the RNA life cycle," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    2. Bella M. Ben-Oz & Feras E. Machour & Marian Nicola & Amir Argoetti & Galia Polyak & Rawad Hanna & Oded Kleifeld & Yael Mandel-Gutfreund & Nabieh Ayoub, 2023. "A dual role of RBM42 in modulating splicing and translation of CDKN1A/p21 during DNA damage response," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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